| 张红,史长征,王晓白,关敏,熊斐,罗良平.不同b值扩散加权成像观察兔急性缺血性横纹肌溶解症[J].中国医学影像技术,2012,28(11):1953~1956 |
| 不同b值扩散加权成像观察兔急性缺血性横纹肌溶解症 |
| DWI observation on acute ischemic rhabdomyolysis of rabbit models using different b values |
| 投稿时间：2012-06-23 修订日期：2012-08-07 |
| DOI： |
| 中文关键词: 横纹肌溶解症 扩散磁共振成像 模型,动物 |
| 英文关键词:Rhabdomyolysis Diffusion magnetic resonance imaging Models, animal |
| 基金项目: |
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| 摘要点击次数: 1928 |
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| 中文摘要: |
| 目的 探讨兔后肢急性缺血性横纹肌溶解症(RM)模型在不同b值下MR DWI中ADC的变化。方法 选取新西兰大白兔23只,手术结扎一侧后肢动脉,制成后肢急性缺血性RM模型(模型组),以未结扎侧作为对照(对照组)。应用GE Signa 1.5T超导MR扫描仪,行DWI扫描,先取b值为0,之后分别取b值为100、200、300、400、500、600、700、800及1000 s/mm2,测量各b值下模型组及对照组股外侧肌的ADC值,并行统计学分析。结果 b＜300 s/mm2及b＞800 s/mm2时,模型组与对照组间ADC值差异均无统计学意义(P均>0.05);300≤b≤800 s/mm2时,ADC值差异均有统计学意义(P均<0.05)。随b值增加,ADC值逐渐下降,DWI信号强度逐渐下降,CNR下降,b≤600 s/mm2时图像质量较好(CNR>5)。结论 DWI可用于早期诊断急性缺血性RM;对于兔后肢急性缺血性RM模型,b=400、500 s/mm2时DWI图像质量良好,ADC测值较准确,能够较为真实地反映病变肌肉的水分子扩散能力。 |
| 英文摘要: |
| Objective To explore the changes of ADC value in DWI with different b values of acute ischemic rhabdomyolysis (RM) rabbit models. Methods Hindlimb RM models were established in 23 New Zealand white rabbits by using ligation. The ligated hindlimbs were defined as model group, and the unligated hindlimbs were defined as control group. DWI with b=0 was performed, and then b value was taken as 100—800 and 1000 s/mm2, and the scanning was performed with GE Signa HD 1.5T System. ADC values of vastus lateralis in model group and control group were measured and statistically analyzed. Results There was no statistical difference between model group and control group in ADC values when b <300 s/mm2 or >800 s/mm2 (all P>0.05), while there was statistical difference between model group and control group when 300 s/mm2≤b≤800 s/mm2 (all P<0.05). The signal intensity of DWI gradually decreased, ADC value gradually decreased and CNR decreased when b value increased. The quality of image was good (CNR>5) when b ≤600 s/mm2. Conclusion DWI can be used in early diagnosis on acute ischemic RM. For acute ischemic RM rabbit models, when b=400 or 500 s/mm2, the quality of image is good and ADC value is accurate, while the diffuse capacity of the diseased muscle can be reflected clearly. |
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