| 林琳,郑容,吴宁,刘瑛,张雯杰,梁颖,赵平.比较三种勾画18F-FDG PET/CT图像中肺癌放疗靶区的方法[J].中国医学影像技术,2012,28(8):1520~1524 |
| 比较三种勾画18F-FDG PET/CT图像中肺癌放疗靶区的方法 |
| Comparison of three methods for delineation gross tumor volume of primary lung cancer on 18F-FDG PET/CT |
| 投稿时间：2012-01-20 修订日期：2012-03-26 |
| DOI： |
| 中文关键词: 氟脱氧葡萄糖F18 正电子发射型体层摄影术 阈值 肺肿瘤 放射疗法 |
| 英文关键词:F18 Fluorodeoxyglucose Positron-emission tomography Threshold Lung neoplasms Radiotherapy |
| 基金项目:卫生部部属(管)医院2010-2012年度临床学科重点项目(136);北京希望马拉松专项基金(LC2011A09)。 |
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| 中文摘要: |
| 目的 比较三种勾画肺癌18F-FDG PET/CT放疗定位图像肺原发病灶大体肿瘤体积(GTV)边界的方法,寻找适合临床应用的肺癌GTV勾画方法。方法 选择14例在18F-FDG PET/CT的CT图像上边界清晰的肺癌病例,在18F-FDG PET图像上分别用40%阈值法(GTV40)、SUV=2.5勾画法(GTV2.5)、公式法(GTV公式)对肺癌原发病灶GTV靶区进行勾画,然后与CT肺窗体积(GTVCT)进行比较。结果 14例肺癌的GTV公式与GTVCT的平均差值小于GTV40与GTVCT体积的平均差值,但差异无统计学意义(P=0.185);GTV公式与GTVCT的平均差值明显小于GTV2.5与GTVCT的平均差值(P=0.0289)。14例肺癌中,12例GTV40小于GTV公式,但二者平均GTV差异无统计学意义(P=0.466)。结论 公式法及40％阈值法均可用于勾画18F-FDG PET/CT放疗定位图像中肺原发病灶的GTV边界,而以SUV=2.5为边界阈值不适合SUV较低的病灶。 |
| 英文摘要: |
| Objective To compare the gross tumor volumes (GTVs) resulting from 3 methods used for defining the gross tumor volume on PET/CT in primary lung cancer, in order to find the suitable method for target volume delineation of lung cancer. Methods Fourteen patients with lung cancer whose PET/CT images were clear were selected. Sets of 3 GTVs were generated for each case by 3 methods: Applying a threshold of 40% of the maximum standardized uptake value (GTV40), using an isocontour of SUV=2.5 around the tumor (GTV2.5), and GTVfunction was obtained from phantom measurements. GTV40, GTV2.5 and GTVfunction were compared with GTVCT, which was determined on CT images of the lung. Results The average difference between GTVfunction and GTVCT was smaller than that between GTV40 and GTVCT, but there was no statistical difference (P=0.185). The average difference between GTVfunction and GTVCT was much smaller than that between GTV2.5 and GTVCT (P=0.0289). In 14 lung cancer patients, GTV40 was smaller than GTVfunction in 12 patients, but there was no significant difference between them (P=0.466). Conclusion Both the regressive function and the threshold 40% of maximum intensity methods can be well applied in lung cancer patients. Taking SUV=2.5 as the threshold is not fit to define the lesions with low SUV. |
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