| 郭建锋,黄敏,吴锦昌,吴传锋.Tei指数和组织多普勒联合N端B型钠尿肽前体评价右心早期放射性损伤[J].中国医学影像技术,2012,28(8):1504~1508 |
| Tei指数和组织多普勒联合N端B型钠尿肽前体评价右心早期放射性损伤 |
| Tei index and tissue Doppler imaging combined with N-terminal proBNP in evaluation of acute radiation induced right heart injury |
| 投稿时间：2011-12-23 修订日期：2012-04-02 |
| DOI： |
| 中文关键词: 心室功能,右 Tei指数 超声检查,多普勒 放射性损伤 |
| 英文关键词:Ventricular function, right Tei index Ultrasonography, Doppler Radiation damage |
| 基金项目:苏州市科技发展项目基金(SS08038)。 |
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| 中文摘要: |
| 目的 探讨Tei指数和组织多普勒成像(TDI)联合N端B型钠尿肽前体(NT-proBNP)评价胸部肿瘤患者放疗后右心早期损伤的价值。方法 对21例接受胸部全程放疗的胸部肿瘤患者,于放疗前、放疗后1天和1个月行NT-proBNP和超声心动图检查,检查指标:①Tei指数;②常规指标,包括三尖瓣血流舒张早期峰值流速(E)、心房收缩期峰值流速(A)、E/A和E峰减速时间;右心室舒张末期内径和右心房收缩末期内径,右心室面积变化率及三尖瓣瓣环运动幅度;③TDI:三尖瓣环内侧和外侧处收缩期峰值速度(Sa)、舒张早期峰值速度(Ea)、舒张晚期峰值速度(Aa)及E/Ea。结果 与放疗前相比,NT-proBNP在放疗后1天明显升高(P<0.05),放疗后1个月降低;放疗后Tei指数升高,Sa、Ea减低,Aa和E/Ea均升高;常规指标在放疗前后无明显变化。结论 胸部肿瘤患者放疗后出现右心功能早期轻度损伤;Tei指数、DTI联合NT-proBNP可对其进行评价。 |
| 英文摘要: |
| Objective To explore the value of Tei index, tissue Doppler imaging (TDI) combined with N-terminal proBNP (NT-proBNP) in evaluating acute radiation induced right heart injury. Methods NT-proBNP and echocardiography were performed in 21 patients underwent thoracic radiotherapy (RT) at the timepoint of before RT, 1 day and 1 month after RT. The following echocardiographic parameters were obtained: ①Tei index; ②Conventional parameters, including the deceleration time of E wave, peak early filling velocity (E), late diastolic filling velocity (A), E/A ratio and deceleration time of E peak, as well as right ventricular end diastolic diameter, right atrium end systolic diameter, right ventricular fractional area change and tricuspid annular plane systolic excursion; ③TDI parameters: Mitral annulus peak velocities in systole (Sa), early diastole (Ea), late diastole (Aa). Then the mitral inflow E velocity to tissue Doppler Ea (E/Ea) was calculated. Results Compared with data before RT, NT-proBNP increased 1 day after RT but declined to a low level a month later (P<0.05), while Sa and Ea decreased, Tei index, Aa and E/Ea increased, but conventional parameters had no significant changes (all P>0.05). Conclusion After RT, TDI, Tei index and NT-proBNP can provide valuable information for evaluating acute radiation induced right heart injury. |
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