| 戴峰,张秀明,吴旻,秦智,张健.BOLD T2*成像评估原发性肝细胞癌患者TACE治疗前、后肝脏血氧含量的变化特点[J].中国医学影像技术,2012,28(5):939~942 |
| BOLD T2*成像评估原发性肝细胞癌患者TACE治疗前、后肝脏血氧含量的变化特点 |
| BOLD T2* imaging in evaluating oxygenation changes of patients with primary hepatocellular carcinoma before and after TACE |
| 投稿时间：2011-11-07 修订日期：2011-12-31 |
| DOI： |
| 中文关键词: 磁共振成像 肝肿瘤 化学栓塞,治疗性 |
| 英文关键词:Magnetic resonance imaging Liver neoplasms Chemoembolization, therapeutic |
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| 中文摘要: |
| 目的 探讨BOLD-fMRI评价原发性肝细胞癌(HCC)患者接受TACE治疗前、后的血氧变化特点及其临床应用价值。方法 对10例HCC患者(HCC组)和10名健康志愿者(对照组)进行BOLD-fMRI扫描,对HCC组患者于TACE术后2~3周内再次行BOLD-fMRI扫描。结果 HCC组和对照组肝实质T2*值分别为(13.90±2.94)ms和(17.94±5.93)ms,差异无统计学意义(P>0.05)。HCC组TACE治疗前、后富血供HCC组织T2*值分别为(31.91±2.07)ms和(7.69±0.75)ms,差异有统计学意义(P<0.01),TACE治疗前、后肿瘤周围肝脏组织T2*值分别为(19.94±3.05)ms和(24.21±1.98)ms,差异有统计学意义(P<0.01)。结论 BOLD-fMRI能有效评测HCC患者TACE治疗前、后非瘤肝脏组织和肿瘤组织内血氧含量的变化特点。 |
| 英文摘要: |
| Objective To investigate the value of BOLD-fMRI in evaluating oxygenation changes in patients with primary hepatocellular carcinoma (HCC) before and after TACE. Methods Ten patients with HCC (HCC group) and 10 volunteers (control group) underwent BOLD-fMRI, and the patients with HCC underwent BOLD-fMRI examination again 2—3 weeks after TACE. Results The mean T2* value of liver tissue in HCC group and control group was (13.90±2.94)ms and (17.94±5.93)ms, respectively (P>0.05). In HCC group, the mean T2* value of tumor tissue with rich blood supply was (31.91±2.07)ms and (7.69±0.75)ms before and after TACE, respectively (P<0.01), while of surrounding liver tissue was (19.94±3.05)ms and (24.21±1.98)ms, respectively (P<0.01). Conclusion BOLD-fMRI can effectively evaluate the oxygenation changes of primary hepatocellular carcinoma before and after TACE. |
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