| 吴秀平,杜毅力,曹永政,彭格红,胡瀚中.探讨超声弹性成像参数与乳腺癌腋窝淋巴结转移及Ki-67表达的相关性[J].中国医学影像技术,2012,28(5):921~924 |
| 探讨超声弹性成像参数与乳腺癌腋窝淋巴结转移及Ki-67表达的相关性 |
| Correlation of ultrasonic elastography parameters with axillary lymph node metastasis and the expression of Ki-67 in breast cancer |
| 投稿时间：2011-12-05 修订日期：2012-01-05 |
| DOI： |
| 中文关键词: 弹性成像 超声检查 乳腺肿瘤 预后 Ki-67抗原 |
| 英文关键词:Elastography Ultrasonography Breast neoplasms Prognosis Ki-67 antigen |
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| 摘要点击次数: 2342 |
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| 中文摘要: |
| 目的 探讨乳腺癌病灶超声弹性成像(UE)中的硬度评分、UE图和二维超声(2D-US)图两种成像模式中的面积比与腋窝淋巴结转移及Ki-67表达有无相关性。 方法 收集经病理组织学证实的乳腺癌患者60例,共60个病灶。对所有患者手术前均行常规超声及UE检查,判断病灶硬度评分,分别测量病灶在UE图与2D-US中的面积,系统软件自动计算面积比值。术后采用免疫组织化学方法测定Ki-67的表达。分析乳腺癌病灶的UE硬度评分、UE图和2D-US图两种成像模式中的面积比与腋窝淋巴结转移及Ki-67表达的相关性。 结果 乳腺癌病灶UE硬度评分与腋窝淋巴结转移和Ki-67表达均无相关性(P均>0.05)。乳腺癌病灶在UE与2D-US两种不同成像模式中测量的面积比与腋窝淋巴结转移无相关性(P>0.05),与Ki-67表达呈正相关(r=0.368,P=0.004)。 结论 UE硬度评分不能作为乳腺癌预后判断的指标。UE与2D-US两种不同成像模式测量的乳腺癌病灶面积比不能预示乳腺癌患者腋窝淋巴结的转移情况,但有助于了解乳腺癌患者癌细胞增殖情况和判断患者预后。 |
| 英文摘要: |
| Objective To explore the correlation of the ultrasonic elastography (UE) scores and the ratios of traced areas in UE versus two-dimensional ultrasound (2D-US) with axillary lymph node metastasis and the expression of Ki-67 in breast cancer. Methods Sixty breast cancer patients with single lesion underwent conventional ultrasound and UE before operation. The lesions were evaluated by elastic scores, and the traced areas of the lesions were measured respectively on UE and 2D-US images, while the ratios of traced areas were automatically calculated by system software. All the patients were confirmed pathologically, and the expressions of Ki-67 were detected by immunohistochemistry technique after operation. The correlation of UE scores and the ratios of traced areas in UE versus 2D-US with axillary lymph node metastasis and the expression of Ki-67 were analyzed. Results No statistical correlation was found between the elastic scores with axillary lymph node metastasis or Ki-67 expression in breast cancer (both P>0.05), nor between the ratios of traced areas in UE versus 2D-US and axillary lymph node metastasis (P>0.05), whereas positive correlation was found between the ratios of traced areas in UE versus 2D-US and Ki-67 expression (r=0.368, P=0.004). Conclusion The elastic score can not be used as the indicator of prognosis judgment of breast cancer. The ratios of traced areas in UE versus 2D-US can not prognosticate axillary lymph node metastasis, but helps to evaluate the proliferation of breast cancer cells and the prognosis of the patients. |
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