| 张贝,王玮,宦怡,赵海涛,崔光彬,白建军.DWI评估内分泌治疗前列腺癌疗效及其与PSA的相关性[J].中国医学影像技术,2012,28(3):554~557 |
| DWI评估内分泌治疗前列腺癌疗效及其与PSA的相关性 |
| DWI evaluation on the therapeutic effect of hormone therapy for prostate cancer and the correlation with PSA |
| 投稿时间：2011-07-19 修订日期：2011-11-08 |
| DOI： |
| 中文关键词: 前列腺肿瘤 扩散加权成像 表观弥散系数 前列腺特异性抗原 |
| 英文关键词:Prostate neoplasms Diffusion weighted imaging Apparent diffusion coefficient Prostate specific antigen |
| 基金项目: |
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| 摘要点击次数: 2585 |
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| 中文摘要: |
| 目的 探讨前列腺癌(PCa)患者内分泌治疗前后DWI表现和ADC值的变化情况及其与PSA的相关性。方法 对22例接受内分泌治疗的PCa患者测量治疗前后ADC值、PSA的变化情况,并对其相关性进行统计学分析。结果 PCa患者治疗前后ADC值分别为(0.82±0.18)×10-3 mm2/s、(1.13±0.35)×10-3 mm2/s,PSA分别为(418.89±1505.71)ng/ml、(330.68±1092.21)ng/ml,差异均有统计学意义;Spearman相关分析结果显示PCa患者治疗前后ADC值与PSA呈负相关(r=－0.763,P<0.0001)。结论 单纯依靠PSA难以全面评估PCa患者治疗前后的病情变化。DWI可作为治疗监测与疗效评估手段,更好地指导临床治疗PCa。 |
| 英文摘要: |
| Objective To evaluate the changes of DWI performances and ADC values in prostate cancer (PCa) patients and their correlation with PSA. Methods Changes of PSA and ADC values of 22 PCa patients before and after hormone therapy were evaluated, and their relevance was statistically analyzed. Results Before and after hormone therapy, the ADC values were (0.82±0.18)×10-3 mm2/s and (1.13±0.35)×10-3 mm2/s, PSA were (418.89±1505.71)ng/ml and(330.68±1092.21)ng/ml (all P<0.05). ADC values and PSA were negatively correlated (r=－0.763, P<0.0001). Conclusion The therapeutic effect of PCa is difficult to evaluate only by PSA. DWI is a better method to guide clinical management and monitor therapeutic effect in patients with PCa. |
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