| 戴西件,龚洪翰,闵友江,王思勇,刘碧霞.fMRI观察静息态下健康人睡眠剥夺前后脑局部一致性差异[J].中国医学影像技术,2012,28(2):243~246 |
| fMRI观察静息态下健康人睡眠剥夺前后脑局部一致性差异 |
| Resting-state fMRI observation on difference of regional homogeneity in healthy subjects after normal sleep and sleep deprivation |
| 投稿时间：2011-06-30 修订日期：2011-10-17 |
| DOI： |
| 中文关键词: 睡眠剥夺 磁共振成像 静息态 神经元自发活动局部一致性 |
| 英文关键词:Sleep deprivation Magnetic resonance imaging Resting state Spontaneous neurogenic activity regional homogeneity |
| 基金项目:国家大学生创新性实验计划(091040307)。 |
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| 中文摘要: |
| 目的 运用fMRI和局部一致性(ReHo)方法观察受试者睡眠剥夺(SD)前后静息态脑神经功能的变化。方法 对15名健康受试者分别在正常睡眠情况下(正常态组)和24 h SD状态下(SD组)间隔2周行静息态fMRI扫描。采用ReHo计算、分析数据,以SPM5软件进行配对t检验分析,设定差异有统计学意义(P<0.001)的体素体积(V)为≥270 mm3。结果 与正常态组比较,SD组ReHo值升高的脑区主要包括左侧额中回,右侧中央前回、颞叶横回,双侧中央后回;ReHo值降低脑区包括左侧额中回、右侧额下回及右侧小脑后叶。结论 SD引起多个脑区形成的网络发生功能紊乱,其中以处于情绪调控环路中的相关脑区变化明显。静息态fMRI可以反映受试者SD状态下脑部功能区ReHo的改变。 |
| 英文摘要: |
| Objective To explore the the difference of abnormal brain activity in healthy subjects after normal sleep and after sleep deprivation (SD) with resting-state fMRI and regional homogeneity (ReHo) method. Methods Totally 15 healthy subjects underwent resting-state fMRI scans after normal sleep (normal situation group) and after 24 h SD (SD group), and the scans were repeated after 2 weeks. ReHo method was used to calculate and analysis the data. SPM5 software was used to perform two-pair t test. P<0.001 and cluster volume more than or equal to 270 mm3 were regarded as statistical significance. Results Compared with normal situation group, SD group showed higher ReHo in left middle frontal gyrus, right precentral gyrus and right transverse temporal gyrus, bilateral postcentral gyrus, while lower ReHo in left middle frontal gyrus, right inferior frontal gyrus and right cerebellum posterior lobe. Conclusion SD caused abnormal changes in whole network changes by connection of multiple brain regions, especially the brain regions which are in emotional control loop. Resting-state fMRI can reflect the changes of ReHo in functional regions of SD subjects. |
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