| 徐丽艳,王海宝,宋文,余永强.颅内血管周细胞瘤MRI表现及病理分析[J].中国医学影像技术,2012,28(2):239~242 |
| 颅内血管周细胞瘤MRI表现及病理分析 |
| MRI and pathological features of intracranial hemangiopericytoma |
| 投稿时间：2011-07-31 修订日期：2011-08-24 |
| DOI： |
| 中文关键词: 血管外皮细胞瘤 磁共振成像 免疫组织化学法 |
| 英文关键词:Hemangiopericytoma Magnetic resonance imaging Immunohistochemistry |
| 基金项目: |
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| 中文摘要: |
| 目的 分析颅内血管周细胞瘤(HPC)的MRI表现,并与病理结果相对照。方法 收集经病理及免疫组化检查确诊的7例HPC患者资料,回顾性分析其临床表现、病理特征及MRI表现。结果 7例HPC中,6例病变位于小脑幕上,1例跨小脑幕上下生长;其中2例小脑幕上病例累及邻近骨质。颅内HPC呈等及稍长T1稍长T2信号,肿块内可见囊变坏死、出血及流空血管,周围见轻度水肿;增强扫描后肿块实质性部分明显强化,2例可见"脑膜尾征",2例累及邻近骨质,1例侵及大脑大静脉及大脑内静脉。免疫组化结果显示7例均见CD34、波形蛋白及CD99表达,上皮细胞膜抗原、细胞角蛋白、胶质纤维酸性蛋白及S-100蛋白均未见表达;对6例进行Bcl-2标记均见表达。对4例进行增殖细胞核抗原Ki-67标记,其中3例为5%~8%表达,1例为10%~15%表达。对3例进行Syn染色,结果均为阴性。结论 MRI对诊断颅内HPC有重要参考价值,但确诊仍依赖于病理和免疫组织化学检查。 |
| 英文摘要: |
| Objective To analyze MRI features of intracranial hemangiopericytoma (HPC) in comparison with pathological findings. Methods The clinical manifestations, pathological features and MRI appearances of 7 patients with HPC confirmed by immunohistochemistry and pathology were analyzed retrospectively. Results Among 7 cases, tumors located above the tentorium in 6 cases, while across the tentorium in 1 case. Adjacent bones were involved in 2 cases of lesions above tentorium. The intracranial HPC manifested as iso-intensity, slight hyper-intensity on T1WI and T2WI with cystic degeneration, hemorrhage as well as flow empty vessels and mild edema around. The solid parts of HPC enhanced markedly after contrast agent was injected. Dural tail sign was seen in 2 cases, the adjacent bones were involved in 2 cases, the great cerebral vein and internal cerebral vein were involved in 1 case. Immunohistochemical examination showed CD34, vimentin and CD99 expression, and epithelial membrane antigen, cytokeratin, glial fibrillary acidic protein and S-100 showed no expression in all 7 cases. Bcl-2 was expressed in 6 cases. Proliferating cell nuclear antigen Ki-67 immunohistochemical staining (n=4) cases revealed 5%-8% expressed in 3 cases, 10%-15% expressed in 1 case, while Syn showed no expression in 3 cases. Conclusion MRI has of important reference value in diagnosis of HPC, but final diagnosis still depends on pathological and immunohistochemical examination. |
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