| 范丽娟,李东,于铁链.MSCT评估冠状动脉钙化:基于每个钙化性斑块的定量测量[J].中国医学影像技术,2012,28(1):101~105 |
| MSCT评估冠状动脉钙化:基于每个钙化性斑块的定量测量 |
| Quantitative measurement of individual coronary artery calcified plaques with MSCT |
| 投稿时间：2011-05-10 修订日期：2011-09-28 |
| DOI： |
| 中文关键词: 冠状血管 动脉粥样硬化 体层摄影术,X线计算机 |
| 英文关键词:Coronary vessels Atherosclerosis Tomography, X-ray computed |
| 基金项目:国家自然科学基金(30870698)、天津市应用基础及前沿技术研究计划(10JCYBJC11000)。 |
|
| 摘要点击次数: 2802 |
| 全文下载次数: 1374 |
| 中文摘要: |
| 目的 初步评估MSCT定量测量冠状动脉钙化(CAC)具体钙化斑块的意义。 方法 分析186例接受CT冠状动脉钙化积分扫描的CAC患者,对每个钙化性斑块进行测量并计算以下各参数值:浓度(CC)、体积(CV)、矿物质量(MM)和钙化积分(AS),并测量所有钙化性斑块整体的参数值:CVtotal、AStotal和MMtotal。以Spearman等级相关进行变量间相关性分析,以秩和检验观察样本间差异。 结果 于186例患者共检出689个钙化性斑块。每个钙化性斑块的CC与CV呈正相关(rs=0.75,P<0.001)。男性CC显著低于女性(P=0.03);55岁以上年龄组CC显著高于≤55岁年龄组(P<0.01)。于86例患者发现多个钙化斑块(n≥3),其CC不均匀程度不依赖于性别(P=0.71)、年龄(P=0.18)和斑块数量(P=0.68)。 结论 具体钙化性斑块的各参数值更能反映冠状动脉粥样硬化的进展和演变特征。CC对评估CAC进展和转归具有重要意义。 |
| 英文摘要: |
| Objective To preliminaryly approach the significance of quantitative measurement of individual coronary artery calcium (CAC) with MSCT. Methods CAC was analyzed in 186 successive patients who underwent CT coronary artery calcium score (CACS) examination. The calcium concentration (CC), calcification volume (CV), mineral mass (MM) and Agatston score (AS) of each individual calcified plaque were measured and calculated, as well as CV, AS, MM of each patient (CVtotal, AStotal, MMtotal). Spearman rank correlation test was used to analyze the relevance between two variables, and rank test was performed to analyze differential significance. Results A total of 689 calcified coronary plaques were identified in 186 patients. High positive correlation was found between CC and CV of each individual calcified plaque (rs=0.75, P<0.001). CC was significantly lower in male than in female (P=0.03), and in patients ≤55 years than >55 years (P<0.01). Multiple calcificated plaques (n≥3) were found in each of 86 patients, and the degree of heterogeneity of CC in these subjects was independent of sex (P=0.71), age (P=0.18) and number of plaques (P=0.68). Conclusion As a new parameter, CC may reflect the general rule of occurrence and progress of coronary artery atherosclerosis diseases, therefore able to providing more information for predicting and evaluating coronary artery atherosclerosis diseases. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
