| 盛丽,唐晓勇,王维斌,强群.彩色多普勒超声观察茴香枳术汤治疗大鼠粘连性肠梗阻的疗效[J].中国医学影像技术,2011,27(12):2415~2418 |
| 彩色多普勒超声观察茴香枳术汤治疗大鼠粘连性肠梗阻的疗效 |
| Color Doppler ultrasound observation on the therapeutic effect of Huixiang Zhizhu soup on experimental rats with adhesive intestinal obstruction |
| 投稿时间：2011-03-27 修订日期：2011-06-24 |
| DOI： |
| 中文关键词: 超声检查,多普勒,彩色 茴香枳术汤 肠梗阻 |
| 英文关键词:Ultrasonography, Doppler, color Huixiang Zhizhu soup Intestinal obstruction |
| 基金项目:甘肃省省自然科学研究基金计划项目(096RJZA042)。 |
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| 中文摘要: |
| 目的 探讨茴香枳术汤(HX-S)治疗大鼠粘连性肠梗阻的有效性。 方法 将108只SPF级Wistar大鼠,随机分为正常组、模型组、大承气汤(DS)组、HX-S低剂量组、中剂量组和高剂量组。对正常组大鼠常规饲养,其余组大鼠按照浆膜剥脱法制成大鼠粘连性肠梗阻模型。造模成功后第8天,对各组分别给予生理盐水、生理盐水、DS、HX-S低、中、高剂量灌胃。治疗后第3、5、7天,应用彩色多普勒超声观察大鼠肠系膜上动脉峰值流速及小肠管壁厚度。 结果 治疗后第3、5、7天,与模型组比较,DS组、HX-S低、中、高剂量组大鼠肠系膜上动脉收缩期峰值流速均明显下降(P均<0.05),小肠管壁厚度基本恢复正常(P均<0.05)。各治疗组比较,HX-S高剂量组疗效较显著。 结论 高剂量HX-S对大鼠粘连性肠梗阻有一定疗效;应用高频彩超可观察疗效。 |
| 英文摘要: |
| Objective To explore the effectiveness of Huixiang Zhizhu soup (HX-S) for the adhesive intestinal obstruction of rat models. Methods Totally 108 SPF Wister rats were randomly divided into normal group, model group, Dachengqi soup (DS) group, HX-S low dosage (HX-SL) group, middle dosage (HX-SM) group and high dosage (HX-SH) group. Rats in normal group were fed normally, and the other rats were made into models of adhesive intestinal obstruction according to serosal stripping method. Seven days later, 0.9% normal saline (NS) was given to rats in normal group and model group, while DS and low, middle and high dosage of HX-S were given to rats in DS group, HX-SL group, HX-SM group and HX-SH group, respectively. Then the peak velocity of superior mesenteric artery (SMA) and bowel wall thickness were observed with color Doppler ultrasound on the 3rd, 5th and 7th day after treatment. Results Compared with model group, peak velocity of SMA on the 3rd, 5th and 7th day after treatment decreased obviously (all P<0.05) in DS group, HX-SL group, HX-SM group and HX-SH group, and the bowel wall thickness returned to normal (all P<0.05). The therapy effect was remarkable in HX-SH group compared with other treatment groups. Conclusion High dosage HX-S is effective to treat adhesive intestinal obstruction of rat models. Color Doppler ultrasound can be used to observe its therapeutic effect. |
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