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李迎辞,于丽娟,田墨涵,王大龙,王文志.Glut1与Ki-67在结直肠癌中的表达及其与¹⁸F-FDG PET/CT SUV_max的相关性[J].中国医学影像技术,2011,27(9):1855~1858

Glut1与Ki-67在结直肠癌中的表达及其与¹⁸F-FDG PET/CT SUV_max的相关性

Expression of Glut1 and Ki-67 of colorectal cancer and its correlation with SUV_max in ¹⁸F-FDG PET/CT

投稿时间：2011-02-10 修订日期：2011-03-26

DOI：

中文关键词: 结直肠肿瘤 18F 氟脱氧葡萄糖正电子发射型体层摄影术体层摄影术,X线计算机 Glut1 Ki-67

英文关键词:Colorectal neoplasms Fluorodeoxyglucose F18 Positron-emission tomography Tomography, X-ray computed Glut1 Ki-67

基金项目:黑龙江省自然科学基金(D200863)。

作者	单位	E-mail
李迎辞	哈尔滨医科大学附属第三医院PET/CT中心,黑龙江哈尔滨 150081
于丽娟	哈尔滨医科大学附属第三医院PET/CT中心,黑龙江哈尔滨 150081	yulijuan2002@yahoo.com.cn
田墨涵	哈尔滨医科大学附属第三医院PET/CT中心,黑龙江哈尔滨 150081
王大龙	哈尔滨医科大学附属第三医院PET/CT中心,黑龙江哈尔滨 150081
王文志	哈尔滨医科大学附属第三医院PET/CT中心,黑龙江哈尔滨 150081

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中文摘要:

目的探讨葡萄糖转运蛋白1(Glut1)与细胞增殖抗原标记物Ki-67在结直肠癌(CRC)中的表达及其与¹⁸F-FDG PET/CT显像最大标准摄取值(SUV_max)的关系。方法对33例经术后病理证实的CRC患者术前进行全身PET/CT检查,记录病灶的SUV_max,用免疫组化方法分析Glut1、Ki-67表达,并与SUV_max进行对比分析。结果 Glut1和Ki-67在CRC中的表达均高于正常组织(t=－4.22、－3.04,P均<0.05)。Glut1在CRC中的阳性表达率显著高于正常组织(χ²=18.94,P<0.05),在低分化CRC中的阳性表达率(5/7,71.42%)高于中-低分化(1/3,33.33%)和中分化(16/23,69.57%)CRC。CRC的 SUV_max与Glut1的表达存在相关性(r=0.63,P<0.05),与Ki-67无相关性(r=0.24,P=0.36)。不同分化程度CRC的SUV_max之间差异无统计学意义(F=0.54,P=0.59);不同肉眼大体分型CRC的 SUV_max之间差异无统计学意义(t=－0.07, P=0.95)。结论 Ki-67可反映CRC细胞的增殖状态;CRC的SUV_max可反映CRC组织中Glut1的表达水平。

英文摘要:

Objective To explore the expression of glucose transporter 1 (Glut1) and Ki-67 of colorectal cancer (CRC) and it's correlation with maximum standard uptake value (SUV_max) in ¹⁸F-FDG PET/CT. Methods Thirty-three patients with CRC proved by postoperative pathology underwent PET/CT imaging preoperatively, and SUV_max of lesions were recorded. The expression of Glut1 and Ki-67 were analyzed by immunohistochemistry, and compared with SUV_max. Results The expression of Glut1 and Ki-67 in CRC were higher than that in normal tissue (t=-4.22, -3.04, both P<0.05). The positive expression of Glut1 in CRC tissue was remarkably higher than in normal tissue (χ²=18.94, P<0.05). The positive expression of Glut1 in poorly differentiated CRC (5/7, 71.42%) was higher than that in the moderately-poorly CRC (1/3, 33.33%) and moderately differentiated CRC (16/23, 69.57%). There was correlation between CRC's SUV_max and Glut1 expression (r=0.63, P<0.05), but not between CRC's SUV_max and Ki-67 (r=0.24, P=0.36). There was no statistical different among different differentiation CRC's SUV_max (F=0.54, P=0.59), nor among different morphologic CRC's SUV_max (t=-0.07, P=0.95). Conclusion Ki-67 can reflect the proliferation level of CRC cells, and SUV_max can reflect the expression level of Glut1 in CRC.

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