| 周晓亮,邓豪余,李新辉,莫逸,谢爱民.非小细胞肺癌血管内皮生长因子表达与18F-FDG PET/CT显像的相关性[J].中国医学影像技术,2011,27(9):1846~1849 |
| 非小细胞肺癌血管内皮生长因子表达与18F-FDG PET/CT显像的相关性 |
| Correlation between vascular endothelial growth factor expression and 18F-FDG PET/CT imaging of non-small-cell lung cancer |
| 投稿时间：2011-02-21 修订日期：2011-05-18 |
| DOI： |
| 中文关键词: 癌,非小细胞肺 正电子发射型体层摄影术 体层摄影术,X线计算机 18F 氟脱氧葡萄糖 血管内皮生长因子A |
| 英文关键词:Carcinoma, non-small-cell lung Positron-emission tomography Tomography, X-ray computed Fluorodeoxyglucose F18 Vascular endothelial growth factor A |
| 基金项目: |
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| 中文摘要: |
| 目的 探讨非小细胞肺癌(NSCLC)18F-FDG PET/CT的显像特点及NSCLC组织血管内皮生长因子(VEGF)表达与18F-FDG摄取间的关系。 方法 对40例NSCLC患者(NSCLC组)和15例肺部良性病变患者(良性组)于术前在同等条件下进行全身PET/CT显像检查,术后取肿瘤组织行VEGF免疫组化检测。采用Mattern半定量分析方法,对肿瘤组织的VEGF表达进行总评分。测定标准化摄取值(SUV),分别对肺部良恶性病变和不同病理类型NSCLC的SUV进行比较;并对肺部良恶性病变的VEGF表达进行评分,分析NSCLC组织VEGF表达评分与SUV的相关性。 结果 NSCLC组肿瘤SUV(5.03±2.89)明显高于良性组(2.05±0.63,P<0.05);不同病理类型NSCLC的SUV差异均无统计学意义(P>0.05);<2 cm与≥4 cm肿瘤间SUV差异有统计学意义(P<0.05);肺结核瘤与鳞癌、腺癌VEGF表达差异均有统计学意义(P均<0.05)。NSCLC组织VEGF表达与SUV相关(r=0.478,P<0.01)。术后6个月内18例患者接受PET/CT复查,7例NSCLC 复发,其VEGF评分明显高于11例肿瘤未复发者(P<0.05)。 结论 测定SUV对于预测NSCLC肿瘤血管增生状况具有一定参考价值。 |
| 英文摘要: |
| Objective To evaluate the imaging characteristics of 18F-FDG PET/CT in non-small-cell lung cancer (NSCLC) patients, and to investigate the correlation between the expression level of vascular endothelial growth factor (VEGF) in NSCLC tissue and 18F-FDG uptake. Methods Forty patients with NSCLC (NSCLC group) and 15 patients with benign lesions (benign group) underwent 18F-FDG PET/CT imaging of the whole body before operation. Tumor tissue were obtained after operation to evaluate the VEGF expression. The level of VEGF expression was measured, and the Mattern half-quantitative analysis was taken to score VEGF expression of the lump tissue. Standardized uptake value (SUV) of all patients were measured on PET/CT imaging, and SUV of benign lesions and different types of malignant lesions of lung were compared. The levels of VEGF expression in the benign and malignant lesions were scored, and the correlation between VEGF expression of NSCLC tissue and SUV of the correspondent patient was analyzed statistically. Results SUV of NSCLC group (5.03±2.89) was higher than that of benign group (2.05±0.63). There was no difference among different pathological types of NSCLC (all P>0.05). There was statistical difference of SUV in NSCLC between <2.0 cm and ≥4.0 cm, as well as of VEGF expression among tuberculoma, squamous cell carcinoma and adenocarcinoma (all P<0.05). There was significant correlation between VEGF expression and SUV (r=0.478, P<0.01) of NSCLC. The score of the VEGF expression was significantly higher in patients with metastasis and/or recurrence (n=7) than in patients with no metastasis and/or recurrence (n=11) 6 months after operation. Conclusion The determination of SUV may be helpful to predict the status of vascular proliferation in carcinoma tissue of NSCLC patients. |
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