| 罗志建,李明星,陈晓梅,宣吉晴,张敏,叶帆,王荔.超声造影监测兔肾缺血再灌注前后肾皮质、髓质血流灌注[J].中国医学影像技术,2011,27(8):1533~1536 |
| 超声造影监测兔肾缺血再灌注前后肾皮质、髓质血流灌注 |
| Contrast-enhanced ultrasound in monitoring renal cortical and medullary perfusion in ischemia reperfusion injury on rabbit models |
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| DOI： |
| 中文关键词: 肾脏 再灌注损伤 造影剂 超声检查 动物实验 |
| 英文关键词:Kidney Reperfusion injury Contrast media Ultrasonography Animal experimentation |
| 基金项目:四川省教育厅科研资助课题(08zc054)。 |
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| 中文摘要: |
| 目的 探讨兔肾缺血再灌注损伤(IRI)前后肾皮质、髓质血流灌注变化的CEUS特征。 方法 建立12只兔肾IRI模型,分别于缺血前及再灌注24 h后行CEUS检查,并对造影的时间-强度曲线(TIC)各参数进行分析。 结果 肾皮质缺血前TIC上升支斜率(Grad)明显高于再灌注24 h后(P<0.05),开始增强时间(AT)、灌注峰值时间(TTP)、曲线下面积(AUC)明显低于再灌注24 h后(P<0.05),肾皮质灌注峰值强度变化(A)值在缺血前及再灌注24 h后无明显改变(P>0.05);肾髓质TTP、AT值在再灌注24 h后较缺血前明显增高(P<0.05),A、AUC、Grad值差异无统计学意义(P>0.05)。 结论 CEUS能够观察兔肾IRI前后肾皮质的血流灌注变化,可为临床无创评价肾损伤提供实验依据。 |
| 英文摘要: |
| Objective To observe CEUS characteristics of renal cortical and medullary before and after renal ischemia reperfusion injury (IRI) on rabbit models. Methods The model of renal IRI were established in 12 rabbits. CEUS was performed on each rabbit before and 24 h after model establishment. The characteristics of parameters of renal perfusion time-intensity curve (TIC) was analyzed. Results The value of gradient between start frame to peak frame (Grad) renal cortical before IRI was significantly higher than that after IRI (P<0.05). The value of arrival time (AT), time to peak intensity (TTP) and area under the cure (AUC) of renal cortical were significantly lower than those after IRI (P<0.05), no significant difference was found in difference between B and the intensity at t=0 (A) of renal cortical before and after IRI (P>0.05). The value of TTP and AT renal medullary before IRI were significantly higher than those after IRI (P<0.05), no significantly difference was found in A, AUC, Grad of renal medullary before and after IRI (P>0.05). Conclusion CEUS monitoring rabbits renal cortical is able to detect changes of perfusion of renal IRI sensitively with the help of analysis of TIC. It can provide some experimental basis for clinical noninvasive evaluating on renal injury. |
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