| 邹利光,张旭升,戚跃勇,张松,文利.HRCT定量观察慢性阻塞性肺疾病患者支气管重构[J].中国医学影像技术,2011,27(7):1383~1387 |
| HRCT定量观察慢性阻塞性肺疾病患者支气管重构 |
| HRCT quantitative observation on bronchi remodeling in patients with chronic obstructive pulmonary disease |
| 投稿时间：2011-01-04 修订日期：2011-03-30 |
| DOI： |
| 中文关键词: 慢性阻塞性肺疾病 体层摄影术,X线计算机 气道重构 |
| 英文关键词:Chronic obstructive pulmonary disease Tomography, X-ray computed Airway remodeling |
| 基金项目:第三军医大学临床科研基金(2009XLC19)。 |
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| 中文摘要: |
| 目的 观察不同临床表型慢性阻塞性肺疾病(COPD)患者肺段和亚段支气管重构的差异。 方法 COPD患者76例,正常对照者30名(正常组),均接受胸部HRCT检查。对双上肺尖后段及亚段、双下肺后基底段及亚段支气管进行定量分析,分别测量4支段和4支亚段支气管的壁厚度(WT)、腔内径(Din)、壁面积(WA)和壁面积百分比(WA%),比较组间各指标差异。 结果 76例COPD患者分为支气管炎型(A组,41例)和肺气肿型(B组,35例)2种临床表型。A组表现为支气管管壁增厚和管腔变窄,以亚段支气管明显;B组表现为肺密度减低和肺气肿,支气管壁增厚不明显或轻度增厚。A、B两组段和亚段支气管WT大于正常组(P<0.05),段支气管Din小于正常组,A组亚段支气管Din小于正常组,差异有统计学意义(P<0.01),A、B两组间差异也有统计学意义(P<0.05)。A组段和亚段支气管WA大于正常组(P<0.05)。A、B两组段和亚段支气管WA%大于正常组(P<0.05),亚段支气管WA%显著大于段支气管(P<0.05)。 结论 HRCT能够检测段和亚段支气管重构,有助于诊断COPD患者临床表型。 |
| 英文摘要: |
| Objective To investigate airway remodeling in different clinical phenotypes of chronic obstructive pulmonary disease (COPD) patients. Methods Chest HRCT was performed in 76 COPD patients and 30 normal subjects (normal group). Wall thickness (WT), inner diameter (Din), wall area (WA), percentage of wall area (WA%) of apical segmental and sub-segmental bronchi of right and left upper lobes, as well as posterior basal segmental and sub-segmental bronchi of right and left lower lobes were measured and statistically analyzed. Results COPD patients were classified into bronchitic phenotype (group A, n=41) and emphysematic phenotype (group B, n=35). The patients of group A showed bronchial wall thickening and luminal narrowing, the changes of sub-segmental bronchi were significant. The patients of group B showed reduced lung density and emphysema, bronchial wall was mild thickened or not thickened. In group A and B, WT of segmental and sub-segmental bronchi were greater than that of normal group (P<0.05). Din of segmental bronchi in group A and B were both smaller than that of normal group, while in group A, Din of sub-segmental bronchi was smaller than that of normal group (P<0.01), and the difference between group A and B was also statistically significant (P<0.05). In group A, WA of segmental and sub-segmental bronchi were greater than those of normal group (P<0.05). WA% of segmental and sub-segmental bronchi in group A and B were both greater than that of normal group (P<0.05), and WA% of sub-segmental bronchi were also greater than that of segmental bronchi (P<0.05). Conclusion HRCT could detect segmental and sub-segmental bronchi remodeling, and is helpful in the diagnosis of COPD phenotypes. |
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