| 杨志勇,全红,月强,任雯廷,曹婷,龚启勇.人脑内脂质代谢产物的磁共振质子波谱[J].中国医学影像技术,2011,27(7):1351~1355 |
| 人脑内脂质代谢产物的磁共振质子波谱 |
| In vivo study of lipid metabolite in human brain with proton magnetic resonance spectroscopy |
| 投稿时间：2010-11-18 修订日期：2011-03-08 |
| DOI： |
| 中文关键词: 磁共振波谱 脑 脂质代谢产物 |
| 英文关键词:Magnetic resonance spectroscopy Brain Lipid metabolite |
| 基金项目:国家自然科学基金(10875092)。 |
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| 中文摘要: |
| 目的 探讨正常人脑脂质代谢产物在不同年龄及不同解剖部位的变化特点。方法 对38名健康志愿者进行1H-MRS扫描,ROI包括双侧海马、左侧丘脑及左侧半卵圆中心脑白质。对不同年龄组(儿童组:≤16岁;青年组:17~29岁;中老年组:≥30岁)及不同解剖部位(海马、丘脑和半卵圆中心脑白质)进行分析,原始波谱数据经LCModel软件处理,并应用SPSS 16.0统计软件包进行数据分析。结果 38名健康志愿者共107个体素中,脑波谱0.9 ppm处脂质代谢产物峰的出现率达91.59%(98/107)。不同年龄组及不同解剖部位间脂质代谢产物含量的差异有统计学意义(P＜0.001)。儿童组中,海马的脂质代谢产物含量高于丘脑(P=0.034);青年组中,海马及半卵圆中心脑白质的脂质代谢产物含量高于丘脑(P＜0.001),且海马的脂质代谢产物含量高于半卵圆中心脑白质(P=0.01);中老年组中,海马的脂质代谢产物含量高于半卵圆中心脑白质和丘脑(P＜0.001)。在半卵圆中心脑白质,青年组的脂质代谢物含量高于中老年组(P=0.004);而在海马和丘脑,不同年龄组间脂质代谢物含量的差异无统计学意义(P=0.065、0.294)。在青年组及中老年组中,半卵圆中心脑白质的脂质代谢物含量与年龄呈负相关(r=-0.63,P=0.004)。结论 正常人脑波谱0.9 ppm处的脂质代谢产物峰可能为某种或某几种正常磷脂代谢的产物。 |
| 英文摘要: |
| Objective To explore the age-related and regional variation of lipid metabolite in normal human brain. Methods Thirty-eight healthy volunteers underwent 1H-MRS, and the scanning sites included bilateral hippocampus, left thalamus and left centrum semiovale of white matter. The various age groups (≤16 years in children group, 17—29 years in youth group, ≥30 years in middle and old aged group) and anatomical regions (hippocampus, thalamus and centrum semiovale of white matter) were analyzed. The original data were post processed with LCModel software, while the statistical analysis was performed using SPSS 16.0. Results Among all the 107 voxels of 38 volunteers, the occurrence rate of the lipid resonance at 0.9 ppm was 91.59% (98/107). The concentrations of lipid metabolite of various age groups and anatomical regions were all significantly different (P＜0.001). Moreover, the lipid metabolite concentration of hippocampus was higher than that of thalamus (P=0.034) in children group, as while as the concentrations of hippocampus and centrum semiovale of white matter were higher than that of thalamus (P＜0.001), and the concentration of hippocampus was higher than that of centrum semiovale of white matter (P=0.01) in youth group. The concentration of hippocampus was higher than that of centrum semiovale of white matter and thalamus (P＜0.001) in middle and old aged group. In centrum semiovale of white matter, the lipid metabolite concentration of youth group was higher than that of middle and old aged group (P=0.004), but there was no statistical difference of the concentration among various age groups in hippocampus and thalamus (P=0.065, 0.294). The lipid metabolite concentration of centrum semiovale of white matter negatively correlated with age in youth group as well as middle and old aged group (r=-0.63, P=0.004). Conclusion The lipid metabolite of normal brain at 0.9 ppm in spectroscopy is possibly a mixture of one or more kinds of sphingolipid metabolites. |
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