| 周颖明,卢霞,王荣福,闫平,张一帆.放射性核素标记 octreotide的体外毒性作用[J].中国医学影像技术,2011,27(7):1344~1347 |
| 放射性核素标记 octreotide的体外毒性作用 |
| Cytotoxicity of octreotide labeled by radionuclide in vitro |
| 投稿时间：2010-11-29 修订日期：2010-12-30 |
| DOI： |
| 中文关键词: 格雷夫斯眼病 细胞毒性,免疫 碘同位素 |
| 英文关键词:Graves ophthalmopathy Cytotoxicity, immunologic Iodine isotopes |
| 基金项目:上海市重点学科建设项目(S30205)、上海市科委自然科学基金(08ZR1414500)、国家重点基础研究发展计划(973计划)项目(2006CB705705)、北京大学985 Ⅱ期基金(985-2-056)。 |
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| 中文摘要: |
| 目的 观察放射性核素 标记的奥曲肽(131I-TOC)对Graves病病理生理过程中不同细胞的毒性作用。 方法 以相同浓度131I-TOC处理增殖期和静止期细胞以及不同性质细胞后,观察131I-TOC的毒性作用;以不同放射剂量的131I-TOC处理活化的成纤维细胞后检测细胞毒性。 结果 131I-TOC对增殖期细胞以及活化的成纤维细胞有明显毒性作用;随着剂量增加,细胞毒性增强。 结论 131I-TOC有望成为治疗Graves病的新方法。 |
| 英文摘要: |
| Objective To observe the cytotoxicity of 131I- octreotide (131I-TOC) to cells involved in the process of Graves ophthalmopathy. Methods 131I-TOC was added to cells in different growth cycle and different cells to assess the toxicity of 131I-TOC to cells. Then the separate dosage of 131I-TOC was cocultured with fibroblast NIH3T3 and the cytotoxicity was measured. Results 131I-TOC had significant cytotoxicity to active fibroblast cells and proliferating cells. Its cytotoxicity was enhanced with increased dosage. Conclusion 131I-TOC might become an effective novel therapy of Graves ophthalmopathy. |
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