| 吴春苗,靳激扬,施鑫,吴旻,邓钢.CT灌注成像在骨肉瘤疗效评价中的应用[J].中国医学影像技术,2011,27(6):1272~1275 |
| CT灌注成像在骨肉瘤疗效评价中的应用 |
| Application of CT perfusion imaging in evaluating therapeutic efficacy for osteosarcoma |
| 投稿时间：2010-12-13 修订日期：2011-02-09 |
| DOI： |
| 中文关键词: 骨肉瘤 灌注成像 体层摄影术,X线计算机 |
| 英文关键词:Osteosarcoma Perfusion imaging Tomography, X-ray computed |
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| 中文摘要: |
| 目的 探讨CT灌注成像(CTPI)在骨肉瘤抗血管生成治疗及化疗疗效判断中的应用价值。方法 将25例原发性骨肉瘤患者随机分为两组:化疗+抗血管生成治疗组(n=14)和化疗组(n=11),对所有病例在治疗前后行64层螺旋CT扫描,分别比较治疗前后肿瘤体积及灌注参数的差别,并对灌注参数与肿瘤微血管密度(MVD)值进行相关性分析。结果 化疗+抗血管生成治疗后,该组患者血流量(BF)、血容量(BV)、Patlak血容量(PBV)和对比剂起始时间(TTS)下降显著(P＜0.05),毛细血管通透性(PS)和对比剂峰值时间(TTP)变化不明显(P＞0.05)。化疗组患者治疗前后各项参数变化均不显著(P＞0.05)。治疗前后两组肿瘤体积改变均无统计学意义(P＞0.05)。两组BF、BV、PBV和PS值均与MVD呈正相关(P＜0.05),TTS、TTP与MVD无相关关系(P>0.05)。化疗+抗血管生成治疗组和化疗组两年生存率分别为84.71%、55.25%,两组生存曲线整体比较具有统计学意义(P＜0.05)。结论 CTPI可为观察骨肉瘤治疗后改变及判断预后提供更多的客观依据。 |
| 英文摘要: |
| Objective To observe the value of CT perfusion imaging (CTPI) in evaluating the therapeutic efficacy of anti-angiogenic therapy and chemotherapy for osteosarcoma. Methods Twenty-five patients with primary osteosarcoma were randomly divided into 2 groups: Chemotherapy plus anti-angiogenic combination therapy group (n=14) and chemotherapy group (n=11). All patients were examined with 64-slice spiral CT before and after treatment. The tumor size and perfusion parameters were measured and compared. Meanwhile, correlative analysis between perfusion parameters and microvessel density (MVD) was done. Results In chemotherapy plus anti-angiogenic combination therapy group, blood flow (BF), blood volume (BV), Patlak blood volume (PBV) and time to start (TTS) decreased significantly after treatment (P＜0.05), while time to peak (TTP) and permeability surface (PS) didn't change significantly (P＞0.05). The perfusion parameters didn't change significantly after treatment in chemotherapy group (P＞0.05). There was no statistically significant change of tumor volume after treatment in all two groups (P＞0.05). BF, BV, PS and PBV had significant positive correlation with MVD (P＜0.05), while TTP, TTS had no significant correlation with MVD (P＞0.05). The survival rate in chemotherapy plus anti-angiogenic combination therapy group and chemotherapy group was 84.71% and 55.25%, respectively (P＜0.05). Conclusion CTPI is more sensitive than morphologic imaging, therefore can provide quantitative parameters to evaluate changes after treatment and prognosis. |
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