| 刘芳,范国光,王慈,徐克,孙文阁.3.0TMR磁敏感加权成像测量帕金森病患者基底节区体积[J].中国医学影像技术,2011,27(3):483~486 |
| 3.0TMR磁敏感加权成像测量帕金森病患者基底节区体积 |
| Measurement of basal ganglia volume of patients with Parkinson disease using 3.0T MR susceptibility-weighted imaging |
| 投稿时间：2010-10-23 修订日期：2010-11-29 |
| DOI： |
| 中文关键词: 帕金森病 基底节 磁共振成像 磁敏感加权成像 |
| 英文关键词:Parkinson disease Basal ganglia Magnetic resonance imaging Susceptibility-weighted imaging |
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| 中文摘要: |
| 目的 应用3.0T磁共振SWI分析帕金森病患者基底节区体积的变化,探讨其诊断帕金森病的价值。方法 采用3.0T MRI对40例早期、中晚期帕金森病患者和年龄匹配的20名正常人进行扫描,分别测量尾状核、壳核及苍白球的体积,并与Hoehn & Yahr分级及病程行相关性分析。结果 早期、中晚期帕金森病患者壳核体积较正常人分别下降10.79%(P＜0.05)和22.66%(P＜0.05),中晚期患者较早期患者下降13.31%(P＜0.05)。中晚期患者苍白球体积较正常人下降11.65%(P＜0.05),较早期患者下降8.51%(P＜0.05)。帕金森病患者壳核体积与Hoehn & Yahr分级呈负相关 (r=－0.987, P＜0.001),与病程无相关性。结论 MRI体积测量技术能为帕金森病的辅助诊断提供一定帮助。 |
| 英文摘要: |
| Objective To analyze changes of basal ganglia volume of patients with Parkinson disease (PD) with 3.0T MR SWI. Methods Totally 20 patients with early PD, 20 patients with advanced PD and 20 age-matched healthy subjects underwent MRI. The volumes of caudate nucleus, putamen and globus pallidus were measured with SWI. Correlation analysis of basal ganglia volume with Hoehn & Yahr grading and the course of PD was carried out. Results Compared with that of normal volunteers, the volume of putamen in patients with early PD decreased 10.79% (P＜0.05), the advanced PD decreased 22.66% (P＜0.05), and the volume of putamen in patients with advanced PD decreased 13.31% than that in patients with early PD (P＜0.05). The volume of globus pallidus in patients with advanced PD decreased 11.65% than that in normal volunteers (P＜0.05), and decreased 8.51% (P＜0.05) than early PD patients. Negative correlation between the volume of putamen and Hoehn & Yahr grading was found (r=－0.987, P＜0.001), but no correlation was found between the volume of putamen and course of disease. Conclusion MRI volumetric measurement technique can provide certain assistance for the diagnosis of PD. |
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