| 赵艳萍,齐玲俊,刘文亚,赵华,郭松禄.CT评价兔VX2肝癌射频消融后局部肿瘤进展模式及部位[J].中国医学影像技术,2011,27(3):474~478 |
| CT评价兔VX2肝癌射频消融后局部肿瘤进展模式及部位 |
| CT evaluation on morphologic patterns and sites of local tumor progression after radiofrequency ablation in rabbit VX2 liver tumor |
| 投稿时间：2010-08-10 修订日期：2010-12-10 |
| DOI： |
| 中文关键词: 癌,肝细胞 导管消融 体层摄影术,X线计算机 动物实验 |
| 英文关键词:Carcinoma, hepatocellular Catheter ablation Tomography, X-ray computed Animal experimentation |
| 基金项目:乌鲁木齐市科学研究与技术开发项目(Y08231007)。 |
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| 中文摘要: |
| 目的 探讨兔VX2肝癌射频消融(RFA)后局部肿瘤进展(LTP)模式和部位的CT特征。方法 新西兰大白兔30只,组织块种植法制成兔VX2肝癌模型,肿瘤种植14天后将荷瘤兔随机分为实验组(n=21)和对照组(n=9),进行RFA治疗。实验组:完全消融肿瘤+至少一个边缘瘤周消融范围小于5 mm正常肝组织;对照组:完全消融肿瘤+肿瘤边缘约10 mm正常肝组织。射频后3、7、14天行CT扫描,每次扫描后选7只实验组、3只对照组兔处死。观察射频区及LTP形态和部位。结果 30只兔单发VX2肝癌模型均成功建模,肿瘤平均直径15 mm,其中5只兔于术中及术后死亡(实验组死亡3只,对照组死亡2只),实验组每次CT检查完成后实际处死6只兔,对照组共7只完成实验。对照组7只兔射频区边缘未见肿瘤细胞;实验组18只兔共发现LTP病灶25个。14只兔的18个LTP病灶发生于射频缘距肿瘤边缘不足5 mm区域内。射频针周围较其他部位更易发生LTP(P=0.011)。结论 VX2肝癌RFA后LTP病灶具有一定特征,LTP的发生与射频消融范围不足有关。 |
| 英文摘要: |
| Objective To detect morphologic patterns and sites of local tumor progression (LTP) with CT in rabbit VX2 liver tumor after radiofrequency ablation (RFA). Methods VX2 tumor tissue blocks were implanted in liver of 30 New Zealand rabbits. Fourteen days after implantation, 30 rabbits with single VX2 hepatic tumor were randomly divided into study group (n=21) and control group (n=9), and RFA was performed. The entire tumor and less than 5 mm peripheral normal margin at least in one side were included in study group, while the entire tumor and about 10 mm peripheral normal margin were included in control group. CT scan was performed 3, 7 and 14 days after RFA. Each time after CT scan, 7 rabbits in study group and 3 rabbits in control group were selected and scarified. Results Single VX2 hepatic tumor was induced into 30 rabbits successfully with average diameter 15 mm. Totally 5 rabbits died before and after RFA treatment, including 3 rabbits in study group and 2 in control group. Each time after CT scan, 6 rabbits in study group were scarified. Seven rabbits in control group completed the experiment. Twenty-five lesions of LTP in 18 rabbits were found in study group, including 18 LTP around insufficient ablated margin, while no viable tumor cells were found around ablative margin in control group. Most LTPs were around the transverse diameter of ablation zone (P=0.011). Conclusion LTP of hepatic VX2 tumor after RFA has some particular morphology. LTP relates to the insufficient of ablation range. |
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