| 郝崴,张莹莹,徐荣天.磁共振灌注成像评估氨基胍对大鼠手术性脑损伤后脑水肿的治疗作用及剂量依赖性[J].中国医学影像技术,2011,27(3):462~465 |
| 磁共振灌注成像评估氨基胍对大鼠手术性脑损伤后脑水肿的治疗作用及剂量依赖性 |
| Magnetic resonance perfusion imaging in rat models of brain edema after surgical brain injury: Analysis of the efficacy and the dose-dependent manner of aminoguanidine |
| 投稿时间：2010-11-19 修订日期：2010-12-22 |
| DOI： |
| 中文关键词: 磁共振成像 灌注成像 氨基胍 脑水肿 创伤和损伤 |
| 英文关键词:Magnetic resonance imaging Perfusion imaging Aminoguanidine Brain edema Wounds and injuries |
| 基金项目: |
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| 中文摘要: |
| 目的 建立动物模型,利用磁共振灌注成像探讨氨基胍(AG)在手术性脑损伤(SBI)后抗脑水肿的作用及其是否存在剂量依赖性。方法 选取成年Sprague-Dawley大鼠80只,建立大鼠SBI模型。建模后将大鼠随机分为治疗组(60只)及对照组(20只)。治疗组平均分为3个亚组,分别于术后以75、150、300 mg/kg体质量腹腔注射AG;对照组则以5 ml/kg体质量腹腔注射5%二甲基亚砜(DMSO)生理盐水。对所有大鼠均于建模后24 h进行磁共振灌注成像,测量脑水肿区局部脑血容量(rCBV)、局部脑血流量(rCBF)及对比剂平均通过时间(MTT)。结果 与对照组相比,150 mg/kg体质量AG治疗亚组rCBV及rCBF明显增高,MTT明显缩短(P均＜0.05)。而75 mg/kg体质量及300 mg/kg体质量AG治疗亚组与对照组rCBV、rCBF及MTT差异均无统计学意义(P均＞0.05)。结论 磁共振灌注成像可观察AG在大鼠SBI后抗脑水肿的作用。AG治疗具有剂量依赖性。 |
| 英文摘要: |
| Objective To investigate the curative effect of aminoguanidine (AG) in the treatment of brain edema after surgical brain injury (SBI) in rat models, and to discuss whether there is a dose-dependent manner with magnetic resonance perfusion imaging. Methods Totally 80 Sprague-Dawley rats were selected, and rat models of SBI were established. Then the rats were divided into treated group (n=60) and control group (n=20) randomly. The rats of treated group were divided into 3 subgroups evenly: Intraperitoneal injections of AG were performed to the rats with the dosage of 75 mg/kg, 150 mg/kg and 300 mg/kg, respectively. Meanwhile, 5% dimethyl sulfoxide (DMSO) saline was injected into rats of the control group with the dosage of 5 ml/kg. Magnetic resonance perfusion imaging was performed on all the rats, and the perfusion parameters in the area of brain edema were measured, including regional cerebral blood volume (rCBV), regional cerebral blood flow (rCBF) and mean transit time (MTT) of contrast media. Results Compared with those of the control group, rCBV and rCBF increased and MTT decreased in the subgroup of 150 mg/kg AG injection (all P＜0.05). No statistical difference of rCBV, rCBF and MTT was found between subgroups of 75 mg/kg, 300 mg/kg AG injection and the control group (all P＞0.05). Conclusion Magnetic resonance perfusion imaging can be used to evaluate the antiedema effect of AG in rat models of brain edema after SBI. There is a dose-dependent manner of AG treatment. |
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