| 路志凯,李健丁,王冠民,张士峰,刘国玉,肖军.CT定量分析2型糖尿病患者腰椎骨密度及其相关因素[J].中国医学影像技术,2011,27(2):384~387 |
| CT定量分析2型糖尿病患者腰椎骨密度及其相关因素 |
| Quantitative CT observation of lumbar vertebrate bone mineral density and the related factors in patients with type 2 diabetes mellitus |
| 投稿时间：2010-08-13 修订日期：2010-09-08 |
| DOI： |
| 中文关键词: 糖尿病,2型 骨密度 骨质疏松 体层摄影术,X线计算机 |
| 英文关键词:Diabetes mellitus, type 2 Bone density Osteoporosis Tomography, X-ray computed |
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| 中文摘要: |
| 目的 探讨2型糖尿病(T2DM)患者腰椎骨密度(BMD)及其相关因素。方法 对127例50~82岁T2DM患者及89名50~83岁的健康体检者(对照组)的L1~3椎体行BMD定量CT(QCT)测定。按年龄和病程分组对两组腰椎BMD及骨质疏松(OP)患病率进行比较,并将腰椎BMD与年龄、病程、体质量指数(BMI)、女性绝经年龄和绝经年限行相关性分析。结果 ①T2DM患者腰椎BMD及OP患病率与对照组间差异均无统计学意义(P>0.05)②男性T2DM不同病程腰椎BMD差异无统计学意义(P>0.05),女性病程10年以上者L2椎体BMD显著低于5年以下者,差异有统计学意义(P<0.05)。③T2DM患者腰椎BMD与年龄呈显著负相关,与BMI呈显著正相关;将年龄作为控制因子,T2DM患者腰椎BMD与病程无相关。④将年龄作为控制因子,女性T2DM患者腰椎BMD与绝经年限呈显著性偏相关(r=-0.216,P<0.05),与绝经年龄无相关。结论 ①T2DM患者腰椎BMD和OP患病率均与正常人基本相似。②随着年龄增长、BMI的减低,T2DM患者腰椎BMD呈下降趋势。③随着绝经年限的延长,女性T2DM患者腰椎BMD呈下降趋势。 |
| 英文摘要: |
| Objective To investigate the changes of lumar vertebrate bone mineral density (BMD) and related factors in patients with type 2 diabetes mellitus (T2DM). Methods Quantitative CT (QCT) was used to measure BMD of lumbar spine in 127 patients with T2DM aged 50—82 years (T2DM group) and 89 healthy subjects aged 50—83 years (control group). BMD of lumbar spine and prevalence rate of osteporosis (OP) with T2DM was compared with normal subjects. The correlation of BMD in T2DM with age, diabetic duration, BMI, menopausal age, and duration after menopausal were analyzed. Results ① BMD of L1—3 and the prevalence rate of OP in the T2DM group were similar to those in the control group (P>0.05). ② BMD of lumar spine in the male T2DM were similar in every diabetic duration group (P>0.05). BMD of L2 in the female T2DM diabetic duration more than 10 years decreased significantly compared with that within 5 years (P<0.05). ③In T2DM group, BMD of lumabar spine had significantly correlation with age, and had significantly correlation with BMI. After adjusting age, the BMD of lumabar spine in T2DM group had no correlation with duration. ④After adjusting age, BMD in female T2DM group had no correlation with menopausal age, and had significantly partial correlation with duration after menopausal (r=-0.216, P<0.05). Conclusion ①BMD of lumabar spine and the prevalence rate of OP in patients with T2DM were similar to those in the control group. ②The reduction of BMD of lumar spine in patients with T2DM is more obvious accompanying with the increasing age and decreasing BMI. ③The reduction of BMD of lumar spine in the female T2DM is more obvious accompanying with the increasing duration after menopausal. |
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