| ZHENG Hai-rong.Ultrasound imaging, drug delivery and therapy: 3 in 1?[J].中国医学影像技术,2010,26(s1):217 |
| Ultrasound imaging, drug delivery and therapy: 3 in 1? |
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| Recent biomedical ultrasound development taking advantage of unique properties of ultrasound contrast microbubbles on ultrasonic molecular imaging, drug delivery and therapy has opened up powerful emerging applications. The microbubbles work by resonating in an ultrasound field, rapidly contracting and expanding in response to the pressure changes of the sound wave. The intense radial oscillation makes them several thousand times more reflective than normal body tissues and emits significantly stronger acoustic signal. As well as being useful in itself, the oscillation resonance that microbubbles produce has several special properties that can be exploited to improve diagnoses. Just as with a musical instrument, multiple harmonic signals are produced. Ultrasound scanners can be designed and tuned to "listen" to these harmonics and produce strong preferential imaging of the microbubbles. The microbubbles are therefore can be used as sensitive acoustic biomarkers in molecular imaging when conjugated with certain proteins. Moreover, due to the large surface area, the microbubbles are wonderful candidates as gene and drug carriers. Selective ultrasound excitation can spatially-manipulate the microbubbles through the mechanism of acoustic radiation force and also destroy microbubbles to release the drug relatively easily. These effects can be useful both in molecular imaging and in localized drug delivery applications. In this seminar, besides background knowledge, I will present a sensitive targeted molecular imaging technique, by taking advantage of high frequency acoustic emission from ultrasound contrast agents, and also recent drug delivery investigations. Based on these preliminarly research, the function of next generation biomedical ultrasound is put forward for discussion: The possiblity of imaging, drug delivery and therapy in one. |
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