| SHEN Bao-zhong,HUAN GTao,WANG Kai,ZHANG Tong,WANG Dan.Molecular imaging research on the effect of endostatin gene therapy in vivo[J].中国医学影像技术,2010,26(s1):121 |
| Molecular imaging research on the effect of endostatin gene therapy in vivo |
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| 作者 | 单位 | | SHEN Bao-zhong | Department of Radiology, the Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, China | | HUAN GTao | Department of Radiology, the Fourth Affiliated Hospital of Harbin Medical University, Harbin 150002, China | | WANG Kai | Department of Radiology, the Fourth Affiliated Hospital of Harbin Medical University, Harbin 150003, China | | ZHANG Tong | Department of Radiology, the Fourth Affiliated Hospital of Harbin Medical University, Harbin 150004, China | | WANG Dan | Department of Radiology, the Fourth Affiliated Hospital of Harbin Medical University, Harbin 150005, China |
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| 中文摘要: |
| Gene therapy has been heralded as a potential revolution in medicine because, for the first time, a therapy is aimed at correcting the cause of disease rather than treating phenotypic symptoms (2001). We report an optical imageable endostatin gene therapy nude mouse model of the Lewis lung tumor cells expressing green fluorescent protein (GFP). Fluorescent imaging of primary and metastatic growth in live tissue and in intact animals are demonstrated. Lewis lung carcinoma (LLC) cells are labeled with GFP and can be seen stably expressing high level of GFP after G418 selection. By transplanting the tumor cells into nude mice, an animal model is established to visualize the tumor's progression and metastasis in vivo by whole body optical imaging. With this model, the therapeutic efficacy of endostatin gene therapy to LLC is monitored continuously. The in vivo imaging pattern provides a powerful model for gene therapy for this disease. |
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