| 赵妍,唐少珊,王一娇,王萤萤,程日.结肠恶性肿瘤的超声造影增强模式及其定量参数与微血管密度的相关性[J].中国医学影像技术,2010,26(12):2317~2320 |
| 结肠恶性肿瘤的超声造影增强模式及其定量参数与微血管密度的相关性 |
| Enhancement pattern of malignant colonic tumors in contrast-enhanced ultrasound images and the correlation between quantitative parameters and microvascular density |
| 投稿时间：2010-06-08 修订日期：2010-08-04 |
| DOI： |
| 中文关键词: 结肠肿瘤 超声检查 微血管密度 时间-强度曲线 |
| 英文关键词:Colonic neoplasms Ultrasonography Microvascular density Time-intensity curve |
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| 中文摘要: |
| 目的 探讨结肠恶性肿瘤的超声造影(CEUS)增强模式及时间-强度曲线特点,分析CEUS定量参数与微血管密度(MVD)的相关性。方法 对19例结肠恶性肿瘤患者行CEUS检查,观察病灶的增强模式,并利用时间-强度曲线获取肿瘤组织及瘤旁肠壁的定量参数。通过术后对肿瘤组织切片进行CD34染色,测得MVD,分析CEUS定量参数与MVD间的相关性。结果 CEUS示19例患者肿瘤均可见不同程度增强,以高增强为主。肿瘤组织与瘤旁肠壁的达峰时间(TTP)分别为(24.4±6.4)s及(31.3±7.6)s,绝对增强强度分别为(11.5±2.9)dB及(6.1±2.3)dB(P均＜0.05)。16例患者肿瘤的时间-强度曲线表现为快速上升快速下降,2例呈快速上升缓慢下降,1例时间-强度曲线呈双峰。病灶的MVD值为(29.1±8.3)条;峰值强度(PI)及始增-达峰时间曲线下面积(AUC of ATP)均与MVD呈正相关(r＝0.80、0.74,P均＜0.01)。结论 CEUS可以动态显示结肠恶性肿瘤的血流灌注情况,定量参数中PI、AUC of ATP与肿瘤MVD具有较好的相关性,可用于术前评估肿瘤血管生成情况。 |
| 英文摘要: |
| Objective To investigate the characteristics of the enhancement pattern and the time-intensity curve of malignant colonic tumors with contrast-enhanced ultrasound (CEUS), and to analyze the correlation between quantitative parameters and microvascular density (MVD). Methods A total of 19 patients with malignant colonic tumors underwent CEUS before operation. The enhancement appearance and the quantitative parameters were observed. The immunohistochemical detection was performed postoperatively to evaluate MVD. The correlation between quantitative parameters and MVD was analyzed. Results Different degrees of enhancement could be found in all patients, while hyper-enhancement was the main manifestation. The value of time to peak (TTP) in tumor tissues and the adjacent bowel wall was (24.4±6.4)s and (31.3±7.6)s respectively, while the absolute enhanced intensity was (11.5±2.9)dB and (6.1±2.3)dB, respectively. There was statistical difference of TTP and the absolute enhanced intensity between tumor tissues and the adjacent bowel wall (all P＜0.05). The time-intensity curve showed quick-up and quick-down in 16 patients, while quick-up and slow-down model was found in 2 patients, and double-peak curve was found in 1 patient. MVD value of the lesions was (29.1±8.3) strips. MVD was positively correlated with peak intensity (PI) and the area under curve of arrival to peak time (AUC of ATP)(r=0.80,0.74, P<0.01). Conclusion CEUS can dynamically display the blood perfusion of malignant colonic tumors. PI and the AUC of ATP have good correlations with MVD, which is helpful to evaluate the angiogenesis of tumors before operation. |
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