| 张苗,卢洁,李坤成,戎冬冬,赵志莲,曹燕翔,赵澄,马青峰.纵向研究脑干梗死的磁共振扩散张量成像与临床预后的相关性[J].中国医学影像技术,2010,26(12):2247~2250 |
| 纵向研究脑干梗死的磁共振扩散张量成像与临床预后的相关性 |
| Longitudinal follow-up study on diffusion tensor imaging and clinical prognosis in brainstem infarction |
| 投稿时间：2010-06-12 修订日期：2010-10-11 |
| DOI： |
| 中文关键词: 脑干梗死 扩散磁共振成像 纤维束成像 |
| 英文关键词:Brainstem infarction Diffusion magnetic resonance imaging Fiber tractography |
| 基金项目:北京市科技新星项目(2009B047)、北京市"十百千"卫生人才培养专项经费。 |
|
| 摘要点击次数: 2423 |
| 全文下载次数: 1071 |
| 中文摘要: |
| 目的 探讨脑干梗死区扩散特征的变化规律及其与临床预后的相关性,观察皮质脊髓束损伤与运动功能恢复的关系。方法 对12例脑干梗死患者,分别于发病7天内、15天、1个月、3个月、6个月进行5次磁共振扩散张量成像(DTI)检查,测量各个时期梗死区部分各向异性分数的相对值(rFA),同时进行临床运动功能评分,并应用扩散张量纤维束成像(DTT)技术进行皮质脊髓束三维重建。分析梗死区rFA值以及皮质脊髓束受累程度与患者运动功能恢复的关系。结果 随发病时间延长,梗死区rFA值逐渐降低(F=11.50,P<0.05),但与临床运动功能评分无明显相关性(P>0.05)。DTT图显示皮质脊髓束无受压、中断者运动功能几乎不受累;皮质脊髓束受压、纡曲或少量中断者运动功能减退,但短期内明显改善;皮质脊髓束大部或全部中断、破坏者运动功能受损严重且恢复缓慢。结论 脑干梗死区rFA值随病程演变呈动态变化,具有规律性;患者皮质脊髓束受累程度与临床症状和运动功能恢复有关,可为预后评价提供重要依据。 |
| 英文摘要: |
| Objective To explore the evolving pattern of diffusion tensor characteristics in brainstem infarction area and the relationship between the evolving pattern and clinical prognosis, and to observe the relationship between corticospinal tract injury and motor function recovery. Methods DTI were performed in 12 patients within 7 days, 15 days, 1 month, 3 months and 6 months after brainstem infarction. The relative fractional anisotropy (rFA) values were measured. Motor function was assessed with Fugl-Meyer scores. Three-dimensional reconstructions of corticospinal tract were performed with DTT technique. The changes of the rFA values in the infarcted areas at different time points and their relation to motor function recovery were studied. The relationship between corticospinal tract injury and motor function outcome was also analyzed. Results The rFA values significantly decreased progressively in the infarcted areas with time going (P<0.05). There was no significant correlation between the rFA values and motor outcomes (P＞0.05). DTT maps showed if the corticospinal tract was not compressed, motor function was almost intact. If the corticospinal tract was compressed, curved or slightly disrupted, motor function was impaired but improved in a short time. When the corticospinal tract was mostly or completely disrupted, motor function was severely impaired and recovered very slowly. Conclusion rFA values in brainstem infarction areas evolve dynamically and in regular patterns. There are relationship between the extent of corticospinal tract injury and clinical manifestations and motor function recovery, which can greatly help the evaluation of clinical prognosis. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
