| 何炜,王维,周平,周鹏.HIFU非热效应诱导兔肝VX2肿瘤损伤[J].中国医学影像技术,2010,26(12):2235~2238 |
| HIFU非热效应诱导兔肝VX2肿瘤损伤 |
| Injury on rabbit hepatic VX2 tumor induced by non-thermal effects of high-intenstiy focused ultrasound |
| 投稿时间：2010-08-05 修订日期：2010-09-08 |
| DOI： |
| 中文关键词: 高强度聚焦超声 兔 肝肿瘤 非热效应 |
| 英文关键词:High-intensity focused ultrasound Rabbits Liver neoplasms Non-thermal effects |
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| 中文摘要: |
| 目的 探讨高强度聚焦超声(HIFU)非热效应机制诱导兔肝VX2肿瘤损伤的效果及其特点。方法 将22只兔肝VX2肿瘤模型随机分为热效应组(n=11)和非热效应组(n=11),在实时测温下行不同参数HIFU辐照,分别诱导热效应和非热效应损伤,结合病理学检查和辐照剂量对肿瘤的损伤情况对比分析。结果 热效应组和非热效应组的时间-温度曲线分别表现为"快速升高、缓慢下降"和"缓慢升高、缓慢下降",损伤体积分别为(1.10±0.22)cm3和(1.21±0.24)cm3(P＞0.05)。辐照区域伴有不同程度的并发症,两组比较差异无统计学意义(P＞0.05);热效应组和非热效应组残瘤率分别为72.73%和18.18%(P＜0.05);破坏最大血管管径分别为(135.27±22.09)μm和(877.64±253.68)μm(P＜0.001)。与热效应组比较,非热效应组的辐照点数明显降低、辐照时间缩短、总时间延长(P均＜0.001),两组间损伤效率差异无统计学意义(P＞0.05)。结论 HIFU非热效应可有效损伤兔肝VX2肿瘤及其滋养血管。 |
| 英文摘要: |
| Objective To investigate the effectiveness and the feature of non-thermal effects of high-intensity focused ultrasound (HIFU) in inducing injuries on rabbit hepatic VX2 tumors. Methods Twenty-two rabbits with hepatic VX2 tumors were randomly divided into thermal effects group (n＝11) and non-thermal effects group (n＝11) before ablation and were ablated with HIFU with thermal and non-thermal effects, respectively. Histopathologic assessment was performed immediately after ablation. Results The time-temperature curves of thermal effects group and non-thermal effects group appeared to be "quick ascending and slow descending" and "slow ascending and slow descending", respectively. The damaged volume, residual tumor rate and maximum diameter of destroyed vessel of the two groups was (1.10±0.22)cm3 vs (1.21±0.24)cm3 (P＞0.05), 72.73% vs 18.18% (P＜0.05) and (135.27±22.09)μm vs (877.64±253.68)μm (P＜0.001), respectively. The ablating dots and time of non-thermal effects group were significantly lower than those of thermal effects group (P＜0.001), while there was no significant difference of necrotic rate between two groups (P＞0.05). Conlusion The non-thermal effects of HIFU could destroy the rabbit hepatic VX2 tumor as well as its feeding vessels effectively. |
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