| 肖喜刚,赵明,张金玲.CT灌注成像观察兔VX2肝癌无水乙醇介入治疗后早期复发[J].中国医学影像技术,2010,26(12):2227~2230 |
| CT灌注成像观察兔VX2肝癌无水乙醇介入治疗后早期复发 |
| CT perfusion imaging observation on early recurrence after alcohol intervention in hepatic VX2 tumor on rabbits |
| 投稿时间：2010-05-07 修订日期：2010-08-11 |
| DOI： |
| 中文关键词: 模型,动物 灌注成像 肝肿瘤 体层摄影术,X线计算机 |
| 英文关键词:Models, animal Perfusion imaging Liver neoplasms Tomography, X-ray computed |
| 基金项目:黑龙江省自然科学基金(D200657)。 |
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| 中文摘要: |
| 目的 观察兔VX2肝癌模型无水乙醇介入治疗后复发的早期CT灌注参数改变。方法 将20只日本长耳大白兔分两组,每组10只,进行肝移植瘤种植。第1组接种VX2移植瘤后2周进行CT灌注成像后处死,进行组织学检查;第2组接种2周后进行无水乙醇介入治疗,且CT灌注扫描动态监测2个月。将采集的灌注参数 与免疫组化结果进行对照。统计学处理采用重复测量方差分析及Spearman相关分析。结果 HBF、PS、HAP、HAF与微血管密度(MVD)均呈正相关(P均<0.05),HBV、MTT与MVD无相关性。介入治疗后第3天,肿瘤边缘PS、HAP增高(P均<0.01),4周时HBF、HBV、PS、HAF、HAP较前及治疗后3天减低(P均<0.01),6周时HBF、HBV、PS、HAF、HAP较4周时增高(P均<0.01),8周较6周时HBF、HBV、PS、HAP增高(P均<0.05)。结论 CT灌注成像能够在显示VX2肝癌血流动力学改变的同时提供精细的解剖图像,对灌注过程进行定量或半定量分析,从而评价肝肿瘤生长及复发情况。 |
| 英文摘要: |
| Objective To observe the early changes of CT perfusion parameters after alcohol intervention in hepatic VX2 tumor on rabbits. Methods Twenty Japanese white rabbits were divided into two groups randomly (each n=10). All rabbits were implanted VX2 tumor tissue into livers to establish tumor models. CT perfusion parameters (blood flow , blood volume , mean transit time , permeability surface , hepatic arterial fraction , hepatic arterial perfusion ) were acquired in group 1 with CT perfusion imaging. Rabbits in group 2 were treated with alcohol intervention two weeks after establishment of models, and the changes of CT perfusion parameters in continuously two months were observed. Statistical repeated measurement, ANOVA analysis and correlation analysis were performed. Results Positivecor relation was found between the values of HBF, PS, HAP, HAF and microvessel density (MVD) (all P<0.05), but not between the values of MTT, HBV and MVD. PS and HAP increased significantly compared with pretreatment in the border of tumor regions 3 days after alcohol intervention (all P<0.01). Four weeks after therapy, the edge of tumor showed lower HBF, HBV, PS, HAF and HAP compared with those pretreatment and 3 days after treatment (all P<0.01). There significantly increased in HBF, HBV, PS, HAF and HAP values between 6 weeks and 4 weeks after treatment. HBF, HBV, PS and HAP increased in 8 weeks compared with those in 6 weeks (all P<0.05). Conclusion CT perfusion imaging can not only show the changes of hemodynamics of VX2 tumors, but also provide meticulous dissection image. Quantitative analysis and semi-quantitative analysis can be done with regard to CT perfusion imaging, which is able to evaluate the growth and early recrudescence of tumor. |
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