| 张超,陈楠,王星,陈霖,杨金柱,赵大哲,李坤成.中国正常成人扣带回体积与年龄的相关性[J].中国医学影像技术,2010,26(11):2048~2051 |
| 中国正常成人扣带回体积与年龄的相关性 |
| Correlation between cingulate gyrus volumes and age of Chinese normal adults |
| 投稿时间：2010-06-23 修订日期：2010-07-17 |
| DOI： |
| 中文关键词: 扣带回 磁共振成像 人体测量 年龄 |
| 英文关键词:Gyrus cinguli Magnetic resonance imaging Anthropometry Age factors |
| 基金项目:国家高技术研究发展计划(863计划)项目(2006AA02z391)、科技部基金项目(2005CB522800、2004CB318101)、国家自然科学基金(30621004)。 |
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| 中文摘要: |
| 目的 分析扣带回体积与年龄的相关关系,揭示扣带回随年龄变化的规律。 方法 对1000名中国健康成年志愿者,按年龄分为A(18~30岁)、B(31~40岁)、C (41~50岁)、D(51~60岁)、E(61~80岁)五组,每组200名,男女各100名,分别接受大脑三维磁化强度预备梯度回波序列T1WI,应用三维体积分析软件测量扣带回的体积,并通过大脑容积标准化处理来校正扣带回体积测量值。不同年龄组扣带回体积的比较采用单因素方差分析,扣带回体积与年龄进行Pearson相关与回归分析。 结果 A~E组校正后扣带回体积(mm3):左侧分别为9734.8±1492.2、9741.8±1754.8、9459.8±1500.4、9421.6±1392.4、9149.7±1471.8,右侧分别为10 673.7±1437.8、10 584.2±1560.8、10 559.8±1495.5、10 258.2±1435.2、9985.0±1472.9,不同年龄组扣带回体积之间差异均有统计学意义(F=5.232、7.428,P均＜0.05),左、右侧扣带回体积与年龄均存在负相关(r=－0.140、－0.167,P均＜0.001)。 结论 扣带回体积与年龄存在线性负相关关系,但相关性不高。 |
| 英文摘要: |
| Objective To analyze the relationship between cingulate gyrus volumes and age, in order to provide basal morphological data for the study of correlative disease. Methods A total of 1000 Chinese healthy volunteers were divided into 5 groups according to age: Group A (18—30), group B (31—40), group C (41—50), group D (51—60) and group E (61—80). Each group consisted of 200 subjects (100 females and 100 males, respectively). Brain scans were performed on all the subjects with T1 weighted three-dimensional magnetization prepared rapid acquisition gradient echo sequence. Cingulate gyrus volumes were semi-manually measured using 3D volume analysis software, and were corrected by total intracranial volume. Cingulate gyrus volumes among different age groups were compared with one-way ANOVA. The relationship between cingulate gyrus volume and age was analyzed with Pearson correlation and regression analysis. Results Corrected cingulate gyrus volumes (mm3) among group A, B, C, D and E were as follows: Left: 9734.8±1492.2, 9741.8±1754.8, 9459.8±1500.4, 9421.6±1392.4 and 9149.7±1471.8; Right: 10 673.7±1437.8, 10 584.2±1560.8, 10 559.8±1495.5, 10 258.2±1435.2 and 9985.0±1472.9. Significant difference was found among different groups (F=5.232, 7.428, all P＜0.05). Cingulate gyrus volumes of both sides were negatively correlated with age (r=－0.140, －0.167, all P＜0.001). Conclusion Cingulate gyrus volumes of both sides have negative linear correlation with age, though the correlation coefficient is not high. |
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