| 李楠,任卫东,靳忠民,刘爽,杨军.超声斑点追踪显像评估收缩性心力衰竭兔的左心室功能[J].中国医学影像技术,2010,26(10):1814~1818 |
| 超声斑点追踪显像评估收缩性心力衰竭兔的左心室功能 |
| Evaluation of left ventricular performance with two-dimensional speckle tracking echocardiography in rabbit models of systolic heart failure |
| 投稿时间：2010-05-07 修订日期：2010-06-24 |
| DOI： |
| 中文关键词: 心力衰竭,充血性 超声心动描记术 心室功能,左 斑点追踪显像 |
| 英文关键词:Heart failure, congestive Echocardiography Ventricular function, left Speckle tracking imaging |
| 基金项目: |
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| 中文摘要: |
| 目的 应用超声斑点追踪显像(STE)评价收缩性心力衰竭(SHF)兔模型的左心室纵向、径向、圆周应变(LS、RS、CS)及扭转运动,探讨左心室扭转相关参数与左心室功能的相关性。 方法 21只雄性新西兰兔随机分为两组:SHF组(n=11)及对照组(n=10)。采用膈下腹腔动脉上方腹主动脉缩窄的方法建立兔SHF模型,2周后应用STE技术测量左心室LS、RS、CS及左心室扭转相关参数,并行左心室导管及心肌病理学检查。 结果 与对照组相比SHF组LS、RS、CS、左心室扭转角度峰值(Ptw)、等容解旋率(IUR)减低,扭转角度达峰时间(tPtw)延迟。SHF组Ptw与左心室舒张末容积(EDV)、收缩末容积(ESV)呈负相关(r=－0.776,P=0.027;r=－0.842,P=0.009),Ptw与射血分数(EF)、左心室压力最大上升速率(＋dp/dtmax)呈正相关(r=0.727,P=0.041;r=0.780,P=0.022)。 结论 STE可有效评价SHF兔的左心室功能,其中Ptw是评价左心室收缩功能的有价值的指标。 |
| 英文摘要: |
| Objective To analyze the left ventricular longitudinal strain (LS), radial strain (RS), circumferential strain (CS) and twist motion in rabbit model of systolic heart failure with two-dimensional speckle tracking echocardiography (STE), and to explore the association between twist-related parameters and left ventricular function. Methods Twenty-one male New Zealand rabbits were randomly divided into two groups: Systolic heart failure group (SHF group, n=11) and control group (n=10). Systolic heart failure was induced by abdominal aortic constriction subdiaphragmly above celiac artery origin for two weeks. Then LS, RS, CS and twist-related parameters were measured with STE. Finally, Left ventricular catheterization and myocardial pathological examination were performed. Results In SHF group, LS, RS, CS, peak twist angle (Ptw), isovolumic untwisting rate (IUR) decreased, time to peak twist (tPtw) delayed compared with control group, and Ptw correlated negatively with EDV, ESV significantly (r=－0.776, P=0.027; r=－0.842, P=0.009), correlated positively with EF, ＋dp/dtmax significantly (r=0.727, P=0.041; r=0.780, P=0.022). Conclusion STE is useful in evaluating left ventricular performance in rabbit models of SHF, and Ptw may be a valuable indices for evaluating systolic function. |
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