| 陈智毅,谢明星.超声靶向破坏微泡技术的应用进展[J].中国医学影像技术,2010,26(9):1790~1792 |
| 超声靶向破坏微泡技术的应用进展 |
| Application progress of ultrasound-targeted microbubble destruction |
| 投稿时间：2010-02-22 修订日期：2010-05-09 |
| DOI： |
| 中文关键词: 超声检查 微泡 基因转移技术 基因治疗 |
| 英文关键词:Ultrasonography Microbubble Gene transfer techniques Gene therapy |
| 基金项目:广东省医学科研基金立项课题(A2010270)。 |
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| 中文摘要: |
| 随着分子生物学及生物技术的迅速发展,近年来基因治疗的基础研究与应用得到了长足进步。超声靶向破坏微泡(UTMD)是一种靶向、高效、有广阔应用前景的非病毒基因输送技术,其通过诱发细胞膜声孔作用,增加膜通透性,进而有效促进大分子物质的胞内传输,且可避免其他基因传输方法的不良反应。本文对UTMD介导基因或药物传递的应用领域予以综述。 |
| 英文摘要: |
| With rapid development of techniques in molecular biology, the progress of gene therapy which is mainly dependent on the development of the methods of gene delivery has promoted. Among non-viral techniques, ultrasound-targeted microbubble destruction (UTMD) is considered as a new method with fewer side effect for organ-specific gene delivery in vitro and in vivo targeting delivery, which can stimulate the micromoleculer transferring into cells efficiently and lay a foundation for cancer gene therapy. The application fields of UTMD mediated gene or drug delivery was reviewed in this article. |
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