| 李素荣,车莉,袁新宇.婴幼儿朗格汉斯细胞组织细胞增生症肺部HRCT表现[J].中国医学影像技术,2010,26(9):1708~1711 |
| 婴幼儿朗格汉斯细胞组织细胞增生症肺部HRCT表现 |
| Pulmonary HRCT findings of Langerhans cell histiocytosis in infants |
| 投稿时间：2010-03-09 修订日期：2010-06-03 |
| DOI： |
| 中文关键词: 组织细胞增多症,朗格汉斯细胞 体层摄影术,X线计算机 婴儿 |
| 英文关键词:Histiocytosis, Langerhans-cell Tomography, X-ray computed Infant |
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| 中文摘要: |
| 目的 探讨婴幼儿朗格汉斯细胞组织细胞增生症(LCH)肺部HRCT表现,分析其与发病年龄、病程之间的关系。方法 回顾性分析23例婴幼儿LCH病例的HRCT资料,依据HRCT表现对患儿分组(间质病变组和结节-气囊组),比较各组发病年龄和病程。结果 HRCT检查阳性率为86.96%;肺部表现包括肺间质病变、孤立或弥漫性结节及气囊。肺间质病变组与结节-气囊组的中位病程分别为3.0(0.7~12.0)个月和6.0(3.0~24.0)个月,前者病程较后者短(P＜0.05)。15例于化疗后复查肺部HRCT,12例恢复正常,2例肺部遗留异常,1例死亡。结论 婴幼儿LCH肺部受累的HRCT表现包括肺部间质病变、结节和(或)气囊,病程早期表现为肺间质病变,后期则以结节、气囊为主要特点。肺内未形成弥漫性结节或气囊者预后良好。 |
| 英文摘要: |
| Objective To study the features of lung high-resolution CT images of Langerhans cell histiocytosis (LCH) in infants, and to analyze the relationship of the CT manifestations with the age at onset and the course of the disease. Methods HRCT of lung for 23 LCH patients were reviewed retrospectively. All patients were divided into two groups (interstitial group, nodule and air-filled cyst group) based on the findings of HRCT. The age at onset and the course of disease were compared between the two groups. Results Abnormal HRCT findings were observed in 20 patients (86.96%), including interstitial lung disease, solitary or diffuse nodules and air-filled cysts. The median course of the two groups was 3.0 (0.7—12.0) months and 6.0 (3.0—24.0) months, respectively. There was significant difference between two groups (P<0.05). Totally 15 patients were followed up with HRCT after chemotherapy, 12 patients returned to normal, 2 patients remained abnormalities, and one patient died. Conclusion HRCT findings of LCH in infants includ interstitial changes, nodules and (or) air-filled cysts. Interstitial changes are the major abnormality in the early stage, and then evolute to nodular and (or) air cystic patterns with aggravation. The patients without diffused nodules and (or) air-filled cysts in the lung would have good prognosis. |
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