| 李长英,陈楠,石林平,梁红琴,杨红,李坤成,王健.原发性开角型青光眼前视路形态变化及与视网膜神经纤维层厚度的关系[J].中国医学影像技术,2010,26(9):1628~1631 |
| 原发性开角型青光眼前视路形态变化及与视网膜神经纤维层厚度的关系 |
| Morphological characteristics of anterior visual pathway and the relationship between morphological changes and retinal nerve fibre layer thickness in patients with primary open-angle glaucoma |
| 投稿时间：2010-06-23 修订日期：2010-07-12 |
| DOI： |
| 中文关键词: 青光眼,开角型 视路 视交叉 磁共振成像 |
| 英文关键词:Glaucoma, open-angle Visual pathways Optic chiasm Magnetic resonance imaging |
| 基金项目:国家863计划项目(2006AA02z391)、国家973计划项目(2005CB522800、2004CB318101)、国家自然科学基金(30870697)。 |
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| 中文摘要: |
| 目的 探讨原发性开角型青光眼(POAG)患者视束、视交叉的形态变化特征,分析其与视网膜神经纤维层厚度(RNFLT)的关系。 方法 对37例POAG患者(POAG组)行全脑磁共振T1加权三维磁化强度预备快速梯度回波序列扫描,利用多基线、多平面重建技术显示视束、视交叉结构,测量视束脑池段横径(TD1)及高径(H1)、视束大脑脚周段横径(TD2)及高径(H2)、视交叉横径(OC-TD)、高径(OC-H)及前后径(APD)。以1000名健康志愿者作为对照组。采用两样本t检验比较两组各径线测量值,采用Pearson检验对POAG组各径线与RNFLT进行相关性分析。 结果 ①POAG组双侧TD1、H1、TD2、H2均小于对照组(P均＜0.05)。②POAG组OC-TD、OC-H小于对照组(P均＜0.05),而两组APD差异无统计学意义(P＞0.05)。③POAG组双侧TD1之和、H1之和、TD2之和及H2之和均与双眼RNFLT之和呈正相关性(r＝0.77、0.77、0.81、0.77,P均＜0.05)。④POAG组OC-TD、OC-H与双眼RNFLT之和呈正相关(r＝0.44、0.60,P均＜0.05),而APD与双眼RNFLT之和无相关性(r＝0.10,P＞0.05)。 结论 POAG患者视束、视交叉萎缩与视网膜神经纤维缺损有关。 |
| 英文摘要: |
| Objective To explore the morphological characteristics of optic tracts and optic chiasma in primary open-angle glaucoma (POAG) patients, and to analyze the relationship between the morphologic changes and retinal nerve fibre layer thickness (RNFLT). Methods Brain MRI was performed in 37 POAG patients (POAG group) and 1000 healthy volunteers (control group) with T1 weighted three-dimensional magnetization prepared rapid acquisition gradient echo (T1W-3D-MP RAGE) sequence. All data of optic tracts and optic chiasma were obtained with multibaseline and multiplanar reconstruction. The diameters of optic tracts and optic chiasma were measured, including the transverse diameter (TD1), the height (H1) of cisternal optic tract, the transverse diameter (TD2) and the height (H2) of peri-crural optic tract, the transverse diameter (OC-TD), the height (OC-H) and the anteroposterior diameter (APD) of optic chiasma. The two sample-t-test was done to compare the diameters between the two groups, while Pearson linear correlation analysis was performed to study the correlation between the diameters and RNFLT. Results ①The measured values of bilateral TD1, H1, TD2 and H2 in POAG group were lower than those of control group (all P＜0.05). ②The OC-TD and OC-H of POAG group were lower than those of control group (all P＜0.05), while there was no statistical difference of APD between the two groups. ③There was positive correlation between the sum of bilateral TD1, H1, TD2, H2 and the sum of binocular RNFLT in POAG group (r＝0.77, 0.77, 0.81 and 0.77, all P＜0.05). ④The sum of binocular RNFLT correlated positively with OC-TD and OC-H (r＝0.44 and 0.60, all P＜0.05), while no correlation was found between APD and the sum of binocular RNFLT (r＝0.10, P＞0.05). Conclusion The atrophy of optic tract and optic chiasma is related to the defect of RNFLT in POAG patients. |
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