| 黄佳,王荣福.碘[131I]治疗14例功能自主性甲状腺腺瘤疗效观察[J].中国医学影像技术,2010,26(8):1546~1548 |
| 碘[131I]治疗14例功能自主性甲状腺腺瘤疗效观察 |
| Effect observation of 131I radiotherapy of autonomous function thyroid adenoma: Analysis of 14 cases |
| 投稿时间：2010-02-23 修订日期：2010-03-18 |
| DOI： |
| 中文关键词: 甲状腺结节 放射性核素显像 |
| 英文关键词:Thyroid nodule Radionuclide imaging |
| 基金项目:973项目(2006CB705705-1)、教育部985II期项目(985-2-056)。 |
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| 中文摘要: |
| 目的 探讨口服碘[131I]治疗功能自主性甲状腺腺瘤(AFTA)的临床疗效。方法 回顾性分析14例AFTA患者,按照临床规范技术操作确诊后并经患者知情同意,给予碘[131I](投入剂量555~1110 MBq)口服治疗。在患者治疗前及治疗后3、6、12个月检测血清T3、T4、TSH、FT3、FT4;服药前后进行甲状腺显像,观察腺瘤在治疗前后的变化。结果 应用131I治疗后1~2个月,瘤体明显缩小,治疗后3~6个月甲状腺显像"热结节"均消失,甲状腺正常组织显影;3个月后血清甲状腺激素水平明显下降;6个月后78.57%的患者甲状腺功能正常,甲状腺功能亢进症状基本消失;1年后甲状腺功能恢复正常者占92.86%。1例在治疗7个月后甲状腺功能减低,经口服优甲乐治疗后甲状腺功能恢复正常。结论 口服碘[131I]治疗功能自主性甲状腺腺瘤是一种安全有效的方法。 |
| 英文摘要: |
| Objective To explore the clinical effect of 131I radiotherapy in treatment of autonomously functioning thyroid adenoma (AFTA). Methods Fourteen AFTA patients took 131I orally at the dose of 555—1110 MBq. The level of serum T3, T4, TSH, FT3 and FT4 were measured before and 3, 6, and 12 months after treatment, respectively. Thyroid imaging with 99mTcO-4 or 99mTc-MIBI was conducted before and 3, 6, and 12 months after treatment respectively, and the change of adenoma was observed. Results Thyroid imaging showed that the adenomas of all patients shrank significantly 1—2 months after 131I treatment, all the hot nodules disappeared, and normal thyroid tissues was shown in the imaging 3—6 months after treatment. Since 3 months after the treatment, the level of serum thyroid hormones began decrease obviously.Six months later, the thyroid functions became normal and the symptoms of hyperthyroidism disappeared in 78.57% of the patients, and 1 year later the thyroid functions resumed normal in 92.86% of the patients. One patient showed hypothyroidism 7 months after the treatment, whose thyroid functions returned to normal after orally taking Euthyrox. Conclusion Orally 131I treatment is a safe and effective method in treatment of AFTA. |
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