| 张丽,谢明星.超声靶向微泡击破介导基因转染或药物传输的研究进展[J].中国医学影像技术,2010,26(7):1366~1369 |
| 超声靶向微泡击破介导基因转染或药物传输的研究进展 |
| Progress of ultrasound-targeted microbubbles destruction mediated gene transfer and drug delivery |
| 投稿时间：2009-11-10 修订日期：2009-12-09 |
| DOI： |
| 中文关键词: 基因转移技术 超声学 |
| 英文关键词:Gene transfer techniques Ultrasonics |
| 基金项目:国家自然科学基金(30670548)。 |
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| 中文摘要: |
| 超声靶向微泡击破(UTMD)是一种新兴的靶向给药及基因转运方法,以超声微泡造影剂作为药物或基因转送的载体,主要作用机制是声孔作用,即胞膜上形成的瞬时孔。超声辐照于靶组织或靶器官,靶部位载基因或载药微泡后靶向释放出基因和药物,提高药物和基因转染率。UTMD为现代的基因治疗提供了一种新的、安全的、非病毒性的转运手段。本文对UTMD技术的作用机制、应用进展及其影响因素进行综述。 |
| 英文摘要: |
| Ultrasound-targeted microbubble destruction (UTMD) has evolved as a new promising method for organ-specific gene delivery in vitro and in vivo targeting delivery via a process which is called sonoporation, allowing for the macromolecule transferring into the cells efficiently. Microbubbles enhance ultrasound energy deposition in the tissues and serve as cavitation nuclei, increasing intracellular drug and gene delivery. UTMD will be an effective, noninvasive gene transfection method and provide a novel, safe non-viral alternative to current gene therapy. Thw mechanism, application progress and influence factor of UTMD were reviewed in this paper. |
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