| 岑东芝,徐莉,张积仁.钼靶X线征象与VEGF表达的相关性[J].中国医学影像技术,2010,26(7):1262~1264 |
| 钼靶X线征象与VEGF表达的相关性 |
| Correlation between mammographic features and vascular endothelial growth factor expression |
| 投稿时间：2010-02-23 修订日期：2010-04-19 |
| DOI： |
| 中文关键词: 血管内皮生长因子 X线 钼 Logistic模型 ROC曲线 |
| 英文关键词:Vascular endothelial growth factors X-rays Molybdenum Logistic models ROC curve |
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| 摘要点击次数: 2631 |
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| 中文摘要: |
| 目的 探讨钼靶X线征象与血管内皮生长因子(VEGF)表达的关系,并建立预测VEGF表达的回归方程,以期指导靶向药物贝伐单抗(AVASTIN)的使用。方法 回顾性分析144例浸润性乳腺癌患者的钼靶X线和病理检查资料,采用t检验和χ2检验进行单因素分析,再行Logistic回归以发现独立的预测指标,建立回归方程;针对各预测指标进行受试者工作特征(ROC)曲线分析, 判断回归方程的预测准确度。结果 单因素分析显示患者年龄、病理分级、肿块直径、肿块分叶征及毛刺征、淋巴结转移6个因素与VEGF蛋白的表达有显著相关性,但进入Logistic回归方程的变量为年龄、肿块直径及淋巴结转移,由回归方程产生各个体预概率P(PRE_1)的ROC曲线下面积为0.88,诊断价值较高。结论 年龄及钼靶X线表现中肿块直径和淋巴结转移对浸润性乳腺癌患者VEGF表达有较好的预测价值,可为临床使用AVASTIN提供指导。 |
| 英文摘要: |
| Objective To investigate the relationship between mammographic features and vascular endothelial growth factor (VEGF) expression, and to establish regression equation to predict the expression of VEGF for guiding clinical application of bevacizumab (AVASTIN). Methods The mammographic appearance and pathological characteristics of 144 patients with invasive breast cancer were collected and were first tested with t test and χ2 test, then analyzed with Logistic regression. Reciever operating characteristic (ROC) curve was used to assess the forecast accuracy of regression equation. Results Univariate analysis showed that expression of VEGF protein was significantly associated with age, pathological grade, tumor size, lobulated sign and mass with spiculation, and lymph node metastasis, whereas only age, tumor size and lymph node metastasis entered into the Logistic regression equation. Area under the ROC curve of pre-probability P (PRE_1) generated by the regression equation was 0.88. Conclusion Patients age, tumor size and lymph node metastasis have better predictive value for VEGF expression in patients with invasive breast cancer, which can provide guidance for clinical use of AVASTIN. |
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