| 高顺禹,崔湧,孙应实,唐磊,李晓婷,张晓鹏.原发性肝细胞癌患者根治术前预后多因素CT分析[J].中国医学影像技术,2010,26(6):1112~1115 |
| 原发性肝细胞癌患者根治术前预后多因素CT分析 |
| Preoperative CT analysis of multi-factors influencing the prognosis of patients with primary hepatocellular carcinoma after radical hepatectomy |
| 投稿时间：2010-03-16 修订日期：2010-04-01 |
| DOI： |
| 中文关键词: 癌,肝细胞 体层摄影术,X线计算机 肝切除术 预后 |
| 英文关键词:Carcinoma, hepatocellular Tomography, X-ray computed Hepatectomy Prognosis |
| 基金项目:国家重点基础研究发展计划(973项目)(2006CB705076)。 |
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| 中文摘要: |
| 目的 探讨原发性肝细胞癌(HCC)患者根治术前增强CT影像学征象与其预后的关系。 方法 回顾性分析87例接受根治切除术的原发性HCC患者术前临床及双期增强CT影像学资料,分析CT征象及根治术后复发转移及生存情况。采用Kaplan-Meier法,Log-rank时序检验进行单因素生存分析,将有统计学意义的指标依次引入Cox比例风险模型进行多因素分析。 结果 全组1、3、5年术后生存率分别为80.18%、65.48%和42.09%。单因素生存分析显示,肿瘤大小、部位(单段病灶与多段病灶)、子灶、血管侵犯、动脉期肿瘤与肝实质CT值比值、门静脉期肿瘤与肝实质CT值比值对预后有影响(P<0.05)。多因素Cox回归分析表明,血管侵犯、门静脉期肿瘤与肝实质CT值比值(<0.85)为影响预后的独立因素(P=0.037、0.007)。 结论 原发性HCC患者根治术后预后不良的主要CT征象包括血管侵犯和门静脉期肿瘤与肝实质CT值比值<0.85。 |
| 英文摘要: |
| Objective To explore the relationship between significant signs on preoperative enhanced CT and the prognosis in patients with primary hepatocellular carcinoma (HCC) after radical hepatectomy. Methods Clinical data and preoperative enhanced CT data of 87 HCC patients who then underwent radical operation were analyzed retrospectively. The status of metastasis and (or) recurrence and survival after surgery were followed for evaluating of prognosis. Univariate survival analysis was applied with Kaplan-Meier method and Log-rank test. Then multivariate analysis was carried out with the Cox proportional hazard method. Results The 1, 3, 5-year postoperative cumulative survival rate of the whole patient group was 80.18%, 65.48% and 42.09%, respectively. Univariate analysis indicated that tumor size, location, satellite nodule, vascular invasion and ratios of tumor to liver parenchyma density in arterial phase and portal phase on CT were risk factors for survival (P<0.05). Further multivariable Cox analysis showed that vascular invasion and ratio of tumor to liver parenchyma density in portal phase on CT were independent significant factors for prognosis (P=0.037, 0.007). Conclusion Vascular invasion and a ratio lower than 0.85 of tumor to liver parenchyma density in portal phase on CT predict poor prognosis after radical hepatectomy in patients with primary HCC. |
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