| 赵芸芸,刘剑羽,徐辉.淋巴瘤的磁共振弥散加权成像及其病理相关性[J].中国医学影像技术,2010,26(6):1001~1004 |
| 淋巴瘤的磁共振弥散加权成像及其病理相关性 |
| Correlation between magnetic resonance diffusion weighted imaging and pathology in lymphoma |
| 投稿时间：2010-02-24 修订日期：2010-04-23 |
| DOI： |
| 中文关键词: 弥散磁共振成像 淋巴瘤 表观弥散系数 |
| 英文关键词:Diffusion magnetic resonance imaging Lymphoma Apparent diffusion coefficient |
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| 中文摘要: |
| 目的 探讨淋巴瘤表观弥散系数(ADC)值与肿瘤细胞密度及淋巴瘤发展进程的相关性。方法 将A20淋巴瘤细胞接种于30只Balb/c小鼠,制备小鼠淋巴瘤模型。对不同阶段的荷瘤小鼠行磁共振弥散加权成像(DWI),观察荷瘤小鼠肿瘤DWI信号,并测量其ADC值。应用Image-J 1.42q软件分析淋巴瘤肿瘤细胞密度。比较淋巴瘤不同发展阶段的ADC值与肿瘤细胞密度的差异,分析二者间的关系及淋巴瘤ADC值与肿瘤发展阶段之间的关系。结果 第三阶段的淋巴瘤ADC值为(0.37±0.08)×10－3 mm2/s,第二阶段的淋巴瘤ADC值为(0.47±0.08)×10－3 mm2/s,第一阶段的淋巴瘤ADC值为(0.69±0.07)×10－3 mm2/s,三者间差异有统计学意义(F=43.13,P<0.05)。第三阶段的淋巴瘤的肿瘤细胞密度(48.85±4.04)%明显大于第二阶段(42.65±4.48)%和第一阶段淋巴瘤肿瘤细胞密度(31.75±4.19)%,三者间差异有统计学意义(F=41.72,P<0.05)。淋巴瘤的ADC值与肿瘤细胞密度呈显著负相关(r=－0.82,P<0.01)。淋巴瘤的ADC值与其发展阶段呈显著负相关(r=－0.84,P<0.01)。结论 ADC值可用于评价淋巴瘤发展进程,分析其生物学特性,判断预后,指导治疗并监测疗效。 |
| 英文摘要: |
| Objective To investigate the correlation of apparent diffusion coefficient (ADC) value with the tumor cellularity of lymphoma and the stage of lymphoma progression. Methods Murine lymphoma models were prepared by A20 cells implantation for 30 Balb/c mice. Diffusion weighted imaging (DWI) was performed in mice of different progression stages. The signal intensities of lesions on the DWI were observed, and the ADC value of them were measured. Cellularity of lymphoma was analyzed using Image-J 1.42q software. The difference in ADC value and tumor cellularity among different stages of lymphoma was compared, the relationship of ADC value with tumor cellularity and the stage of lymphoma progression was analyzed. Results The mean ADC (in units of 10－3 mm2/s) value of lymphomas at stage Ⅲ (0.37±0.08) was significantly lower than that of stage Ⅱ (0.47±0.08) and Ⅰ(0.69±0.07) (F=43.13, P<0.05). The mean cellularity of lymphomas at stage Ⅲ (48.85±4.04)% was significantly higher than that of stage Ⅱ (42.65±4.48)% and Ⅰ (31.75±4.19)% (F=41.72, P<0.05). There was significantly negative correlation between ADC value and tumor cellularity (r=－0.82, P<0.01), also between ADC value and the stage of lymphoma progression (r=－0.84, P<0.01). Conclusion ADC value can be used to evaluate the progression of lymphoma. Therefore, it is helpful in analyzing the biological property, predicting prognosis, guiding treatment and monitoring the effect of their treatments. |
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