| 白芝兰,戚威,张晓娜,李敏.孤独症患儿胼胝体磁共振形态及扩散张量成像[J].中国医学影像技术,2010,26(5):825~827 |
| 孤独症患儿胼胝体磁共振形态及扩散张量成像 |
| Structural MRI and diffusion tensor imaging of corpus callosum in autism |
| 投稿时间：2010-01-15 修订日期：2010-01-29 |
| DOI： |
| 中文关键词: 孤独症 胼胝体 磁共振成像 扩散磁共振成像 |
| 英文关键词:Autism Corpus callosum Magnetic resonance imaging Diffusion magnetic resonance imaging |
| 基金项目: |
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| 中文摘要: |
| 目的 通过胼胝体磁共振形态及扩散张量成像(DTI)观察孤独症患儿胼胝体形态及细微结构异常,探讨其可能的发生机制。方法 对13例男性孤独症患儿(孤独症组)及15名正常男童(正常对照组)进行胼胝体结构磁共振形态及DTI观察,测量胼胝体正中矢状面前部、体部、后部及总面积,大脑总体积及各相异性分数(FA),并对两组进行对比分析。结果 孤独症组胼胝体前部面积及总面积较正常对照组减小(P<0.05),体部和后部面积与对照组差异无统计学意义(P>0.05);大脑总体积较对照组增大(P<0.05)。孤独症组患者胼胝体前部和体部的FA值明显低于正常对照组(P<0.05),后部的FA值两组间差异无统计学意义(P>0.05)。结论 孤独症患儿胼胝体前部面积较正常发育儿童明显减小,胼胝体前部及体部FA值明显降低,提示胼胝体局部白质纤维束可能存在微结构的改变。 |
| 英文摘要: |
| Objective To investigate the microstructural abnormalities of the corpus callosum (CC) in autism with structural imaging and diffusion tensor imaging (DTI), and to detect its mechanisms. Methods Thirteen autistic boys (autism group) and 15 healthy boys (control group) underwent MR structural DTI and scanning. The areas of 3 subregions (anterior, body and posterior) and their total area, total brain volume (TBV) and fractional anisotropy (FA) value of the CC were measured and compared between the two groups. Results The anterior and total area of the CC in autism group were lower than those in control group (P<0.05), but no statistical difference was found in body and posterior CC (P>0.05). TBV in autism group was significantly larger than that in control group (P<0.05). FA value in the anterior and body of CC was lower than that in control group (P<0.05), but no difference was found in posterior CC between two groups (P>0.05). Conclusion There may be disruption of regional white matter tracts in the anterior and body of the corpus callosum in patients with autism. |
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