| 景香香,刘洁,杨炳昂,符少清,吴汤娜,王东林.超声联合造影剂对正常大鼠关节滑膜组织的生物学作用[J].中国医学影像技术,2010,26(4):609~611 |
| 超声联合造影剂对正常大鼠关节滑膜组织的生物学作用 |
| Bioeffects of ultrasound combined with contrast media on joints synovial of normal rats |
| 投稿时间：2009-11-11 修订日期：2009-12-06 |
| DOI： |
| 中文关键词: 超声检查 造影剂 关节 滑膜 动物,实验 |
| 英文关键词:Ultrasonography Contrast media Joints Synovial membrane Animals, laboratory |
| 基金项目:国家自然科学基金(30860270)、海南省自然科学基金(30854)。 |
|
| 摘要点击次数: 2546 |
| 全文下载次数: 852 |
| 中文摘要: |
| 目的 观察诊断超声联合不同剂量超声造影剂对正常关节滑膜组织的生物学作用。 方法 20只正常清洁级Wister大鼠,分5组(每组4只,8个膝关节):超声＋100 μl造影剂、超声＋200 μl造影剂、超声＋300 μl造影剂、超声＋500 μl造影剂、单纯超声照射(对照组)。各组均使用诊断超声持续照射10 min。1周后处死大鼠,取关节滑膜组织行HE染色,观察大鼠关节滑膜组织有无损伤及损伤情况。 结果 超声＋100 μl造影剂、超声＋200 μl造影剂及超声＋300 μl造影剂、单纯超声照射各组未发现关节滑膜组织有明显损伤。在超声＋500 μl造影剂组发现滑膜细胞肿胀,呈圆形、椭圆形或多边形,滑膜组织增生明显,层次明显增多,排列紊乱,周围组织中毛细血管增生明显,部分肌纤维结构溶解断裂,炎性细胞浸润。 结论 超声联合造影剂能明显增强对滑膜组织的生物学效应,且造影剂剂量越大,滑膜组织损伤越严重。 |
| 英文摘要: |
| Objective To observe the bioeffects on the normal rats synovial with diagnostic ultrasound combined with different doses contrast medium. Methods Twenty normal cleaning level Wister rats were divided into 5 groups (each with 4 rats and 8 knees): ultrasound+100 μl contrast medium, ultrasound+200 μl contrast medium, ultrasound+300 μl contrast medium, ultrasound+500 μl contrast medium, a simple ultrasound irradiation (control group). Each group was irradiated with diagnostic ultrasound for 10 min. Rats were sacrificed after 1 week and joints synovial tissues were observed with pathological HE staining. Results In group ultrasound+100 μl contrast medium, ultrasound+200 μl contrast medium, ultrasound+300 μl contrast medium and control group, no significant damage in synovial tissues was found. In group ultrasound+500 μl contrast medium, synovial cells swelling, showing round, oval or polygonal, synovial tissues hyperplasia, arranged disorder, capillary proliferation, some muscle fiber structure dissolved fracture, inflammatory cell infiltration in the surrounding tissue were found. Conclusion Ultrasound combined with contrast medium can significantly enhance the bioeffects of synovial tissues, and the more the contrast medium doses, the more serious injury occurs in synovial tissues. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
