| 徐丽艳,钱银锋,赵本胜,余永强,刘斌.外周原始神经外胚层肿瘤的MRI表现和病理对照(附7例分析)[J].中国医学影像技术,2010,26(3):448~451 |
| 外周原始神经外胚层肿瘤的MRI表现和病理对照(附7例分析) |
| MRI and pathological features of peripheral primitive neuroectodermal tumors: Analysis of 7 cases |
| 投稿时间：2009-09-06 修订日期：2009-11-10 |
| DOI： |
| 中文关键词: 神经外胚层肿瘤,原始,外周 磁共振成像 免疫组织化学 |
| 英文关键词:Neuroectodermal tumors, primitive, peripheral Magnetic resonance imaging Immunohistochemistry |
| 基金项目: |
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| 中文摘要: |
| 目的 分析外周原始神经外胚层肿瘤(pPNET)的MRI表现,并与病理结果相对照。方法 收集经病理及免疫组化检查确诊的7例pPNET患者资料,回顾性分析其临床表现、病理特征及MRI表现。结果 7例pPNET中,2例位于颅内,2例位于下肢,1例位于椎管内并跨椎管内外生长,1例位于盆腔内并累及骶骨,1例位于腹膜后。软组织内pPNET呈等T1、稍高T2信号,内可见囊变坏死及出血,1例边缘可见假包膜,增强后肿瘤实性部分明显强化,侵犯周围骨组织。骨pPNET表现为溶骨性骨质破坏,伴有较大的软组织肿块。免疫组化结果显示7例均见CD99表达,4例突触素表达,3例嗜铬粒蛋白表达,2例神经元特异性烯醇酶表达,2例波形蛋白表达,1例上皮细胞膜抗原表达。结论 MRI对外周原始神经外胚层肿瘤的诊断有重要参考价值,确诊仍依赖于病理和免疫组织化学检查。 |
| 英文摘要: |
| Objective To analyze MRI features of peripheral primitive neuroectodermal tumor (pPNET) in comparison with pathological findings. Methods The clinical manifestation, pathological features and the MRI appearances of 7 patients with pathologically proved pPNET were analyzed retrospectively. Results Among 7 patients, 2 patients located in intracalvarium, 2 in lower extremities, 1 in vertebral canal and extended outside of vertebral canal, 1 in cavitas pelvis and involved sacrum, and the rest 1 in the retroperitoneal space. The lesions in soft tissue manifested as iso-intensity on T1WI, slight hyper-intensity on T2WI with cystic degeneration and hemorrhage. Pseudo-capsule was seen in 1 patient. The solid parts of pPNET enhanced markedly after the contrast agent was injected. The adjacent bones were usually involved. pPNET in bone presented as osteolytic destruction of bone with large soft tissue mass. Immunohistochemical examination showed CD99 expression in all 7 patients, synaptophysin (Syn) expression in 4, Chromogranin (CgA) expression in 3, neuron specific enolase (NSE) expression in 2, vimentin (Vim) expression in 2 and EMA in 1 patient. Conclusion MRI has important reference value in diagnosis of pPNET, but final diagnosis still depends on the pathological and immunohistochemical examination. |
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