| 蔡振刚,刘晓黎,高晓军,蔡叶萍,王忠裕.背向散射积分技术评价大鼠原位肝脏移植病理损害[J].中国医学影像技术,2010,26(3):432~434 |
| 背向散射积分技术评价大鼠原位肝脏移植病理损害 |
| Evaluation of hepatic pathological damage after orthotopic liver transplantation with integrated backscatter in rats |
| 投稿时间：2009-08-23 修订日期：2009-10-13 |
| DOI： |
| 中文关键词: 背向散射积分 肝移植 病理学 大鼠 |
| 英文关键词:Integrated backscatter Liver transplantation Pathology Rats |
| 基金项目: |
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| 摘要点击次数: 2667 |
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| 中文摘要: |
| 目的 应用背向散射积分(IBS)技术评价原位肝移植(OLT)后大鼠肝脏病理损害。方法 32只SD大鼠,40只Wistar大鼠,按不同处理方法分组。建立SD-Wistar OLT模型,分为4组:对照组:8只未予药物干预;CsA组:8只给予环孢素A 30 mg/(kg·d);SIN组:8只给予青藤碱40 mg/(kg·d);CsA+SIN组:8只给予青藤碱40 mg/(kg·d)+环孢素15 mg/(kg·d)。正常组:8只Wistar大鼠,为空白对照。术后4天、10天测量肝脏的IBS值 ,术后10天处死大鼠取肝脏组织行病理检查。结果 术后4天AII对照组和SIN组较正常组、CsA组、SIN+CsA组增高(P＜0.05);CsA组、SIN+CsA组高于正常组(P＜0.05)。术后10天组间AII对比:CsA组、SIN+CsA组、SIN组较对照组明显下降(P＜0.05)。PPI、SDI术后4天、10天各组内及组间比较差异均无统计学意义(P＞0.05)。大鼠肝移植后肝脏病理损害程度与IBS呈正相关(r=0.814,P＜0.01)。结论 测定移植肝脏的IBS有助于判断移植肝脏损害的程度。 |
| 英文摘要: |
| Objective To evaluate the hepatic pathological damage after orthotopic liver transplantation (OLT) in rats with integrated backscatter (IBS). Methods Thirty-two SD rats and 40 Wistar rats were included, and stable OLT models were established except 8 Wistar rats as blank group. The rat models were randomly divided into 4 groups (each n=8): normal group (given no treatment), CsA-treated group (30 mg/ ), SIN-treated group (40 mg/ ), SIN and CsA-treated group (SIN 40 mg/ +CsA 15 mg/ ). Hepatic IBS (peak to peak intensity: PPI; average image intensity: AII; standard deviation of image intensity: SDI) was measured on 4th and 10th day after OLT. The rats were sacrificed and a part of liver was cut off for pathological examination. Result Four days later, AII of control and SIN groups were higher than those in other groups (P<0.05), and of CsA-treated and SIN+CsA-treated groups were higher than that of blank group (P＜0.05), while no difference of PPI and SDI was detected between each two groups. Ten days later, AII in CsA-treated, SIN+CsA-treated and SIN-treated groups were lower than that of control group (P＜0.05), no difference of PPI and SDI was detected between each two groups. IBS was positively correlated with liver pathological damage (r=0.814, P＜0.01). Conclusion Detecting hepatic IBS contributes to the diagnosis of the level of liver damage after OLT. |
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