| 牛洪涛,张文丽,郭启勇,于兵,马丽.对比剂稳态磁化率MR灌注成像评价大鼠C6胶质瘤抗血管生成治疗的疗效[J].中国医学影像技术,2010,26(3):425~428 |
| 对比剂稳态磁化率MR灌注成像评价大鼠C6胶质瘤抗血管生成治疗的疗效 |
| Assessment of therapeutic effect of anti-angiogenesis in rat C6 glioma with steady-state susceptibility contrast-enhanced MR perfusion imaging |
| 投稿时间：2009-09-16 修订日期：2009-11-10 |
| DOI： |
| 中文关键词: 胶质瘤 内皮抑素 磁共振成像 血管生成 |
| 英文关键词:Glioma Endostastin Magnetic resonance imaging Angiogenesis |
| 基金项目: |
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| 中文摘要: |
| 目的 探讨对比剂稳态磁化率MR成像技术评估大鼠C6胶质瘤抗血管生成治疗疗效的价值。方法 17只荷瘤大鼠随机分成治疗组(n=8)和对照组(n=9)。治疗组腹腔注射人重组内皮抑素(10 mg/kg),对照组腹腔注射相同剂量的生理盐水,共7天。治疗前、后分别行MR检查,测量肿瘤周边区、肿瘤中央区及对侧相应正常脑实质区的血容量(BV)和血管管径指数(VSIMRI)值,并与病理结果相对照。结果 治疗后治疗组与对照组肿瘤体积差异有统计学意义(t=5.26,P<0.05)。治疗后肿瘤中心区及周边区BV和VSIMRI值均有下降,以肿瘤周边区下降更为明显(t=4.14、3.66,P均<0.01)。结论 对比剂稳态磁化率MR成像技术评估人重组内皮抑素治疗鼠C6脑胶质瘤具有可行性,能够准确反映治疗前后肿瘤BV和VSI的变化。 |
| 英文摘要: |
| Objective To explore the of value steady-state susceptibility contrast-enhanced MRI (SSCE-MRI) in assessment of anti-angiogenesis therapy in rat C6 glioma. Methods Seventeen rats with the bearing-tumor were randomly divided into the therapy group (n=8) and the contrast group (n=9). Human-recombination endostatin (10 mg/kg) was injected to animals in therapy group, and saline of the same dose was injected to the contrast group for 7 days. Blood volume (BV) and vessel size index (VSI) were measured of tumors in peripheral, central and normal areas with MR pre- and post-therapy. Results After therapy of endostatin, the tumor volume was obviously different between therapy group and contrast group (t=5.26, P<0.05). BV and VSIMRI of tumor decreased in both peripheral and central areas, particularly in the peripheral area (t=4.14, 3.66, all P<0.01). Conclusion Assessment of therapeutic effect of anti-angiogenesis in C6 glioma is feasible with SSCE-MRI, and it can reflect the changes of BV and VSIMRI pre- and post-therapy. |
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