| 王志红,刘怀军,吴文新,徐英进,宋利宏,田泽君,王藏海.兔颈动脉急性血栓的MRI分子影像学评价[J].中国医学影像技术,2010,26(3):414~417 |
| 兔颈动脉急性血栓的MRI分子影像学评价 |
| Molecular MRI evaluation of acute thrombus in carotid artery in rabbits |
| 投稿时间：2009-08-12 修订日期：2009-11-19 |
| DOI： |
| 中文关键词: 兔 颈动脉 血栓形成 磁共振成像 分子影像学 |
| 英文关键词:Rabbits Carotid arteries Thrombosis Magnetic resonance imaging Molecular imaging |
| 基金项目:河北省自然基金(c2006000927)。 |
|
| 摘要点击次数: 2080 |
| 全文下载次数: 800 |
| 中文摘要: |
| 目的 评价纤维蛋白靶向结合MRI对比剂(EP-2104R)对兔颈动脉急性血栓的显示能力,并与非对比增强和Gd-DTPA增强MR进行对比。 方法 用颈动脉外部损伤和阻塞的方法制作5只兔颈动脉内血栓模型,在血栓诱导后急性期(6.0 h)进行对比剂EP-2104R注入前及注入后MR扫描,并与组织病理学对比。 结果 纤维蛋白靶向对比剂能准确显示血栓,优于非对比增强MRI和Gd-DTPA增强MRI(P<0.001)。Gd-DTPA增强后不能提高发现血栓的能力。 结论 纤维蛋白靶向对比剂在显示活体内急性血栓方面优于非对比增强和Gd-DTPA增强MRI。 |
| 英文摘要: |
| Objective To assess the value of a fibrin-targeted contrast agent (EP-2104R) for MR detection of thrombus, and to compare this modality with non-contrast-enhanced (NCE) MRI and Gd-DTPA injection at acute period after thrombus generation. Methods Thrombus was induced with external injury and stasis in 5 rabbits. MRI was performed before and after contrast agent injection at 6.0 h after injury, and the MRI findings were compared with that of histopathologically examinations. Results EP-2104R enhanced MRI accurately detected thrombus, which was superior to both NCE and Gd-DTPA injection (P<0.001). Gd-DTPA injection was not associated with improvement of thrombus detection. Conclusion Being a fibrin-targeted MR contrast agent for in vivo detection of acute thrombus, EP-2104R is superior to NCE MRI and Gd-DTPA injection. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
