| 刘佳,张萍,刘政,赵洋,高顺记,皋月娟,高云华.不同参数的超声辐射力对微泡造影剂的作用[J].中国医学影像技术,2010,26(2):225~227 |
| 不同参数的超声辐射力对微泡造影剂的作用 |
| Effect of ultrasound radiation force on microbubble contrast agents with different exposure parameters |
| 投稿时间：2009-06-22 修订日期：2009-11-18 |
| DOI： |
| 中文关键词: 超声检查,介入性 微泡 推移 聚集 |
| 英文关键词:Ultrasonography, interventional Microbubble Displacement Aggregation |
| 基金项目:国家自然科学基金面上项目(30772070)。 |
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| 中文摘要: |
| 目的 研究不同参数(如声压、频率、辐照时间)所致的超声辐射力对流动状态下的微泡造影剂的作用。方法 建立微血管流体模型,通过体视显微镜观察并记录不同的辐照参数对微泡造影剂的推移、聚集现象,对比分析不同辐射力对微泡的作用。结果 固定声强时,频率为2.0 MHz的超声波对微泡的推移与聚集作用大于1.0 MHz和0.5 MHz;低声压超声对微泡无明显破坏作用,但使其流速减慢;浓度为7×107个/ml时微泡聚集现象较浓度为7×105个/ml时明显,当微泡浓度高达7×109个/ml时,超声辐射力对微泡无明显的推移;延长辐照时间对微泡的推移和聚集作用无明显影响。结论 不同参数的超声辐射力对微泡造影剂的推移和聚集作用不同,可望通过调整辐射力参数来最大程度地提高微泡的靶向黏附率。 |
| 英文摘要: |
| Objective To investigate the effect of microbubble (MB) contrast agents impacted by different parameters such as acoustic pressure, frequency, duration of exposure, and MB concentration under flowing condition. Methods A capillary flow mimic model was set up for observation and analysis of MB displacement and aggregation under stereomicroscope. Results The displacement and aggregation of ultrasonic occurred significantly at the frequency of 2.0 MHz than 1.0 MHz and 0.5 MHz. Under low acoustic pressure, MBs were not visually disrupted but the flow slowed down. The aggregation and deflection applying to MB was stronger in the tube happened at the MB concentration of 7×107/ml than 7×105/ml, but did not when the concentration rose to 7×109/ml because of the high viscosity. The ultrasound exposure time could not affect significantly in displacement and MB aggregation. Conclusion MB contrast agents can be manipulated under some ultrasound parameters. It is expected to be physically modulated in blood vessels, in order to increase targeted adhesions for many therapeutic purposes. |
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