| 刘丽华,张明,王渊.脑胶质瘤基质金属蛋白酶9表达与磁共振成像特征的相关性[J].中国医学影像技术,2009,25(12):2197~2200 |
| 脑胶质瘤基质金属蛋白酶9表达与磁共振成像特征的相关性 |
| Relationship between matrix metalloproteinase-9 expression and MRI characteristics of glioma |
| 投稿时间：2009-05-15 修订日期：2009-06-23 |
| DOI： |
| 中文关键词: 基质金属蛋白酶 磁共振成像 神经胶质瘤 |
| 英文关键词:Matrix metalloproteinase Magnetic resonance imaging Glioma |
| 基金项目:陕西省自然科学基金(2001SM84)。 |
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| 摘要点击次数: 2028 |
| 全文下载次数: 1028 |
| 中文摘要: |
| 目的 探讨脑胶质瘤MMP-9表达与肿瘤病理分级、磁共振成像(MRI)特征的关系。方法 31例胶质瘤患者分为低级别组(Ⅰ、Ⅱ级)20例、高级别组(Ⅲ、Ⅳ级)11例, 术前均接受MR平扫及增强扫描。以免疫组化染色观察MMP-9表达,并与MRI瘤周水肿指数(EI)、强化程度(EP)及肿瘤最大直径相比较。结果 高级别胶质瘤组MMP-9表达、EI、EP、肿瘤最大直径显著高于低级别胶质瘤组(t=6.312、4.405、6.286和5.026,P均＜0.05)。MMP-9表达与肿瘤EI、EP、最大直径呈正相关(r=0.516,0.554和0.676,P＜0.05)。MMP-9表达在边界清晰和不清晰肿瘤间差异无统计学意义(t=0.906,P>0.05),而在信号均匀与不均匀肿瘤间差异有统计学意义(t=2.637,P＜0.05)。结论 MMP-9表达与脑胶质瘤侵袭性密切相关,MRI所示瘤周水肿、肿瘤强化程度、肿瘤最大直径、信号均匀与否反映MMP-9表达,可作为判断肿瘤恶性的指标。 |
| 英文摘要: |
| Objective To investigate the levels of matrix metalloproteinase-9 (MMP-9) expression in different grades of glioma and the relationship with MRI characteristics. Methods Thirty-one patients of glioma confirmed pathologically were divided into two groups: low grade group (grade Ⅰ and Ⅱ, n=20) and high grade group (grade Ⅲ and Ⅳ, n=11). MMP-9 expression levels were evaluated with immunohistochemical staining. Plain and enhanced MR scan were performed in all patients before operation. Peritumoral edema index (EI), enhance percentage (EP) and the tumor’s maximum diameter were recorded as characteristics of MRI. Results The expression levels of MMP-9, EI, EP and the tumor’s maximum diameter were significantly higher in the high grade group than those in the low grade group (t=6.312, 4.405, 6.286 and 5.026, respectively, all P＜0.05). The expression of MMP-9 were found significantly correlated to EI, EP and the maximum diameter of tumor (r=0.516, 0.554 and 0.676, respectively, all P＜0.05). The expression levels of MMP-9 were significantly different between tumors with heterogeneity and even signal (t=2.637, P＜0.05), but not between tumors with unclear border and clear border definition (t=0.906, P>0.05). Conclusion MMP-9 expression have close relationship with invasion of glioma. EI, EP, the maximum diameter and signal of tumor can reflect the level of MMP-9 expression, and may be used to estimate tumor’s malignant behavior, being able to provide the evidence for future clinical operation. |
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