| 李娜,李亚明.18F-FDG PET/CT诊断恶性肿瘤骨转移瘤[J].中国医学影像技术,2009,25(9):1697~1699 |
| 18F-FDG PET/CT诊断恶性肿瘤骨转移瘤 |
| 18F-FDG PET/CT diagnosis of skeletal metastases |
| 投稿时间：2009-02-20 修订日期：2009-05-09 |
| DOI： |
| 中文关键词: 氟脱氧葡萄糖 F18 体层摄影术,发射型计算机 体层摄影术,X线计算机 肿瘤转移 骨和骨组织 |
| 英文关键词:Fluorodeoxyglucose F 18 Tomography, emission-computed Tomography, X-ray computed Neoplasm metastases Bone and bones |
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| 中文摘要: |
| 目的 通过分析肿瘤患者骨转移瘤病灶PET及CT表现的特点及二者关系,提高PET/CT在骨转移瘤诊断中的作用。 方法 对25例恶性肿瘤骨转移瘤患者行18F-FDG PET/CT显像。阳性病灶采用5点评分法,3分或4分的病灶定为PET骨转移瘤病灶;获得病灶18F-FDG最浓聚处的最大SUV值(SUVmax)。CT显像中破骨病变、成骨病变、成骨破骨混合病变诊断为恶性病变。 结果 PET显像发现骨转移瘤病灶159个,CT发现152个,差异无统计学意义(χ2＝0.574,P＞0.05)。CT成骨病灶与破骨病灶及混合病灶的PET显像阳性率差异均有统计学意义(χ2＝47.33,χ2＝7.93, P＜0.01)。PET和CT显像均为阳性的122个病灶中,CT成骨改变29个,病灶平均SUVmax为(5.76±3.41);破骨病灶84个,平均SUVmax为(8.52±5.37),成骨破骨混合病灶9个,平均SUVmax为(7.78±4.96)。成骨病灶与破骨病灶的平均SUVmax差异有统计学意义(t=2.28, P＜0.05)。 结论 PET对成骨病变漏诊较多,PET及CT相结合能明显提高诊断的准确性。 |
| 英文摘要: |
| Objective To observe the efficacy of 18F-FDG PET/CT in diagnosing bone metastases, and PET and CT features of bone metastases and their correlation. Methods A total of 25 patients with malignant tumors underwent 18F-FDG PET/CT scan. Metastasis lesions were assessed with 5-point scale and grade 3 or 4 were defined as bone metastasis. The maximum standard uptake value (SUVmax) was calculated automatically in the region with maximum uptake of 18F-FDG. Lytic, sclerotic, mixed lytic-sclerotic changes on CT images were considered malignancy. Results PET scan and CT identified 159 and 152 malignant lesions, respectively (χ2＝0.574, P＞0.05). Statistical difference of positive ratio of PET was found between osteoblastic and osteolytic or mixed lesions (χ2＝47.33, 7.93, both P＜0.01). Of the 122 positive lesions both at CT and PET, the mean SUVmax was (5.76±3.41) in 29 osteoblastic lesions, (8.52±5.37) in 84 osteolytic lesions and (7.78±4.96) in 9 mixed lesions, respectively. There was significant difference between osteoblastic and osteolytic lesions (t=2.28, P＜0.05). Conclusion PET scan alone may miss osteoblastic lesions, whereas combined with CT images, PET can obviously improve the diagnosis. |
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