| 鹿存芝,王跃涛,曹苏生,王伟,王冠民,刘军,朱峰,鹿峰,刘德峰.PET/CT诊断分化型甲状腺癌失分化患者复发及转移灶[J].中国医学影像技术,2009,25(8):1470~1472 |
| PET/CT诊断分化型甲状腺癌失分化患者复发及转移灶 |
| PET/CT in the detection of recurrence and metastasis of dedifferentiated thyroid carcinoma |
| 投稿时间：2009-03-13 修订日期：2009-04-19 |
| DOI： |
| 中文关键词: 甲状腺癌 18F-氟代脱氧葡萄糖 正电子发射体层摄影术 复发 肿瘤转移 |
| 英文关键词:Thyroid neoplasms Fluorodeoxyglucose F18 Positron-emission tomography Recurrence Neoplasm metastasis |
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| 中文摘要: |
| 目的 探讨18F-氟代脱氧葡萄糖(18F-FDG) PET/CT显像对甲状腺球蛋白(TG)阳性而131I-诊断剂量全身显像(dWBS)阴性的分化型甲状腺癌(DTC)复发和转移的诊断价值。 方法 15例TG阳性而dWBS阴性DTC患者均接受18F-FDG PET/CT检测,以术后组织病理学或至少6个月的临床和影像学随访结果为诊断病灶性质的标准,得出其灵敏度和阳性预测值(PPV),并比较术前、术后TG变化。 结果 18F-FDG PET/CT诊断DTC复发和转移的灵敏度和阳性预测值分别为93.33%和91.43%,术后TG值较术前TG值明显下降(P＜0.05)。 结论 对于TG阳性而131I-dWBS阴性DTC患者的复发和转移,18F-FDG PET/CT是一种非常有用的检测手段和判断是否须行外科手术的可靠依据。 |
| 英文摘要: |
| Objective To evaluate the role of PET/CT with FDG-18F in the detection of recurrence and metastasis of differentiated thyroid carcinoma (DTC) in patients with elevated levels of thyroglobulin (TG) and negative whole body scan (WBS). Methods Fifteen DTC patients with high TG levels but negative dWBS underwent PET/CT scan. The diagnosis standard was based on histopathologic findings or clinical and imaging follow-up within 6 months. The sensitivity and positive value were obtained, and the preoperative and postoperative levels of TG were compared. Results For detecting the recurrence and metastasis of DTC, the sensitivity and positive predictive value (PPV) of PET/CT was 93.30% and 91.43%,respectively. The postoperative levels of TG descended obviously after preoperation. Conclusion PET/CT scan with 18F-FDG is an effective and non-invasive method in the detection of recurrence and metastasis of DTC with high TG levels but negative dWBS, making it a reliable guide for surgical planning. |
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