| 赵龙,柳曦,史河水,韩萍,喻杰.实验兔胡桃夹综合征模型的建立及其MSCTA评价[J].中国医学影像技术,2009,25(8):1347~1350 |
| 实验兔胡桃夹综合征模型的建立及其MSCTA评价 |
| Establishment of nutcracker syndrome model in rabbits and evaluation with multi-slice CT angiography |
| 投稿时间：2009-02-10 修订日期：2009-03-21 |
| DOI： |
| 中文关键词: 胡桃夹综合征 体层摄影术,X线计算机 模型,动物 兔 |
| 英文关键词:Nutcracker syndrome Tomography, X-ray computed Models, animal Rabbits |
| 基金项目: |
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| 摘要点击次数: 1871 |
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| 中文摘要: |
| 目的 制作适于影像学研究的胡桃夹综合征(NCS)的动物模型,并应用MSCTA评价左肾静脉(LRV)的形态学变化。方法 30只新西兰大白兔,随机分为LRV 50%结扎组(A组)、LRV 75%结扎组(B组)和对照组(C组),每组10只。采用探针腔外与LRV并行结扎的方法建立动物模型,A、B两组分别结扎LRV近下腔静脉(IVC)侧断面的50%和75%,并于结扎前后分别行MSCTA检查,测量并评价LRV的狭窄面积。通过C组与A、B组间LRV－IVC压差的测定,评估模型的可靠性。 结果 A与B组LRV实际和理论结扎狭窄面积差异均无统计学意义(P>0.05),A、B两组结扎后与C组比较LRV－IVC压差明显增大,其绝对值≥5 cmH2O,差异有统计学意义(P<0.05)。 结论 通过腔外结扎LRV制作的动物模型可真实地模拟NCS时LRV的形态和压力改变,MSCTA可对其进行客观评价。 |
| 英文摘要: |
| Objective To establish rabbit models of the nutcracker syndrome (NCS) suitable for imaging, and to evaluate the morphology of left renal vein (LRV) with multi-slice CT angiography (MSCTA). Methods Thirty rabbits were randomly divided into 3 groups (each n=10 ), i.e. group A (LRV ligation of 50％), B (LRV ligation of 75%) and C (control group). With extra-luminal ligation on LRV with touch needle, NCS rabbit models were established. The 50% and 75% cross section area of LRV near inferior vena cava (IVC) in group A and group B were ligated respectively, the actual stenosis extent of LRV before and after ligation were measured with MSCTA, and the reliability of the models were evaluated using the LRV－IVC differential pressure measured among group A, B and C. Results No significant difference of stenosis extent of LRV before and after ligation was found between group A and B (P>0.05). LRV－IVC pressure was significant different between group A and C (P<0.05), as well as group B and C (P<0.05), and the absolute values were both more than 5 cm H2O. Conclusion Establishment of NCS rabbit models with extra-luminal ligation in different percentages is easy-performing, and can simulate changes of shape and pressure for NCS actually. MSCTA could be used to evaluate the changes objectively. |
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