| 曾祥柱,李选,高文清,余若晖,刘晨.MSCTP成像结合CTA评价兔慢性骨骼肌缺血侧支动脉生成和灌注恢复[J].中国医学影像技术,2009,25(8):1339~1342 |
| MSCTP成像结合CTA评价兔慢性骨骼肌缺血侧支动脉生成和灌注恢复 |
| MSCT perfusion imaging combined with CT angiography evaluation of collateral artery growth and perfusion recovery in rabbit model of hind-limb ischemia |
| 投稿时间：2009-05-17 修订日期：2009-05-22 |
| DOI： |
| 中文关键词: 血管造影术 灌注 骨骼肌 缺血 侧支动脉 体层摄影术,X线计算机 |
| 英文关键词:Angiography Perfusion Muscle, skeletal Ischemia Collateral artery Tomography, X-ray computed |
| 基金项目: |
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| 摘要点击次数: 2018 |
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| 中文摘要: |
| 目的 探讨CT成像在评价骨骼肌血流灌注改变和侧支动脉生长中的应用价值。 方法 利用10只新西兰大白兔建立一侧后肢的缺血模型,分别于术后3、7、14、21、42 d行MSCTP成像和CT血管造影(CTA)检查,分析两侧后肢小腿腓肠肌感兴趣区(ROI)的时间-密度曲线(TDC)和相关灌注参数特点,并对生成的侧支动脉计数。 结果 术后3 d术侧后肢血流灌注较对侧急剧减少,TDC相对峰值和各项灌注指标(BF、BV、MTT及PS)在术后7 d内恢复非常缓慢,较健侧均有明显差异(P＜0.01);术后7 d开始灌注恢复逐渐加快, 14~42 d相对峰值、PS与MTT及BV逐步接近正常水平,但BF在42 d仍有差异(P＜0.05)。7 d内侧支动脉生成较少,7~21 d生成增多(P均＜0.01),21~42 d侧支动脉生成缓慢(P=0.257);CTA侧支动脉与相对峰值、BF和BV明显相关(R2=0.56、0.51和0.56, P均＜0.001)。 结论 缺血肌组织血流的恢复与侧支动脉的生成相关;CTP结合CTA成像能够无创、定量、较准确地评估动物后肢缺血模型随时间推移发生的肌肉组织灌注和侧支动脉形成情况。 |
| 英文摘要: |
| Objective To assess the value of CT in evaluating changes of muscle blood perfusion and collateral artery growth. Methods Ten New Zealand white rabbits were used to make ischemia models in the lateral hind limb. MSCT perfusion (MSCTP) and CTA were performed on models 3, 7, 14, 21, 42 d after the model establishment, respectively. CT value of relative peak of time-density curve (TDC) and perfusion parameters (BF, BV, MTT, PS) were analyzed, and the number of collateral arteries scored with CTA were measured. Results After the operation, a rapid reduction of muscle perfusion in the hind-limb was observed on the 3rd day (P<0.01). Perfusion recovered very slowly during the first 7 days, while faster perfusion recovery was observed within 7 to 42 days, S (relative value), BF, BV, MTT and PS reached the normal level from 14th to 42nd day, but at last BF did not reach the normal level (P<0.05). CTA showed significant collateral growth from 7th to 21st day (all P＜0.01) and increased slowly from 21st to 42nd day (P=0.257). Significant positive correlation was observed between CTA collateral score and S (relative value), BF, BV (R2=0.56, 0.51 and 0.56, all P＜0.001). Conclusion Vascular recovery significantly relates to collateral vessel growth in rabbit model of hind-limb ischemia. Based on MSCTP and CTA, time-dependent changes of muscle perfusion and collateral arteriogenesis can be non-invasively and quantitatively assessed with relative accuracy. |
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