| 张春燕,任转琴,孙洪跃,王霄英,蒋学祥.大范围扩散加权成像检测恶性肿瘤骨转移瘤:与骨扫描相对照[J].中国医学影像技术,2009,25(7):1258~1261 |
| 大范围扩散加权成像检测恶性肿瘤骨转移瘤:与骨扫描相对照 |
| Application of large field diffusion-weighted imaging in the detection of bone metastases of malignant tumors: comparison with bone scintigraphy |
| 投稿时间：2008-11-24 修订日期：2009-04-19 |
| DOI： |
| 中文关键词: 磁共振成像 放射性核素显像 骨肿瘤 肿瘤转移 |
| 英文关键词:Magnetic resonance imaging Radionuclide imaging Bone neoplasms Neoplasm metastasis |
| 基金项目: |
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| 中文摘要: |
| 目的 评价大范围扩散加权成像(DWI)在恶性肿瘤骨转移瘤检测中的应用。 方法 18例手术证实的各种恶性肿瘤患者纳入本研究。所有患者均在1个月内同时接受大范围DWI检查和99mTc-MDP骨扫描检查。 结果 18例患者中,15例经常规MRI证实存在骨转移瘤,其中7例为多发骨转移瘤(>10处),另8例共证实23处转移瘤;余3例未见转移瘤。除外7例全身多发骨转移瘤(>10处)患者,对其余11例有(8例)或无(3例)骨转移瘤患者计数病灶数,以患者为单位计算的大范围DWI和骨扫描诊断骨转移瘤的敏感性均为100%,特异性分别为100%、33.33%;曲线下面积分别为1.00和0.67,差异有统计学意义(P=0.04)。以病灶为单位计算的大范围DWI和骨扫描诊断骨转移瘤灶的敏感性分别为86.96%、78.26%,特异性均为60.00%;曲线下面积分别为0.74和0.69,差异无统计学意义。 结论 大范围DWI可用于恶性肿瘤骨转移瘤的筛查。 |
| 英文摘要: |
| Objective To evaluate large field diffusion-weighted imaging (DWI) in detection of bone metastases of malignant tumors. Methods Eighteen patients with various malignant tumors were enrolled in this study. All the patients underwent large field DWI and 99mTc-MDP bone scintigraphy within one month. Results Fifteen of 18 patients were diagnosed as bone metastases with conventional MRI; 7 of them were found more than 10 bone metastases, and 23 bone metastases were confirmed in the other 8 patients. When seven patients with multiple bone metastases (>10) were excluded, and lesions in the residual 11 patients with or without bone metastases were counted, the diagnostic sensitivity of bone metastases with large field DWI and bone scintigraphy was both 100%, and specificity were 100% and 33.33%, respectively. ROC study showed the area under curve (AUC) of large field DWI and bone scintigraphy were 1.00 and 0.67, respectively (P=0.04). With lesion numbers as study unit, the diagnostic sensitivity of large field DWI and bone scintigraphy were 86.96% and 78.26%, and the specificity was both 60.00%. ROC study showed the AUC of large field DWI and bone scintigraphy was 0.74, 0.69, respectively; and no statistical difference was found. Conclusion Large field DWI can be used in screening the bone metastases of malignant tumors. |
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